摘要
目的探讨缬沙坦对糖尿病大鼠肾脏糖化终末产物受体(RAGE)表达的影响,探索其肾保护机制。方法30只大鼠分为正常对照组、未处理糖尿病组和缬沙坦治疗组(n=10)。12周后测定各组大鼠肾质量/体质量比、血糖、糖化血红蛋白、24 h尿蛋白定量和血脂改变,并以实时定量PCR法测定RAGE表达水平。结果未处理糖尿病组大鼠肾质量/体质量比、24 h尿蛋白定量和肾组织RAGE表达均显著高于正常对照组;与未处理糖尿病组相比,缬沙坦治疗组大鼠肾质量/体质量比、24 h尿蛋白定量和肾组织RAGE表达显著下降。结论缬沙坦可抑制糖尿病大鼠肾脏肥大,并降低尿蛋白排泄率,这种肾保护作用可能与其抑制RAGE表达有关。
Objective To investigate the effects of valsartan on the expression of receptors for advanced glycation endproducts（RAGE） in kidneys of diabetic rats, and to explore its renoprotection mechanisms. Methods Thirty rats were divided into normal control group, diabetes control group and diabetes with valsartan group（ n = 10）. Blood glucose, blood lipid, HbAlc, kidney to body weight ratio and 24 h urinary protein excretion were measured after 12 weeks. RAGE mRNA level was detected by real-time quantitative PCR. Results Compared with normal control group, kidney to body weight ratio, 24 h urinary protein excretion and RAGE mRNA were significantly increased in diabetes control group. Compared with diabetes control group, kidney to body weight ratio, 24 h urinary protein excretion and RAGE mRNA were significantly decreased in diabetes with valsartan group. Conclusion Valsartan can inhibit renal hypertrophy and decrease urinary protein excretion in diabetic rats. The renoprotective effects may be related to its inhibition on RAGE expression.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2008年第5期501-504,共4页
Journal of Shanghai Jiao tong University:Medical Science
关键词
缬沙坦
糖化终末产物受体
糖尿病大鼠
肾保护
valsartan
receptor for advanced glycation end-products
diabetic rat
renoprotection
