摘要
目的:观察维持性血液透析(MHD)患者由静脉铁剂诱导的氧化应激状态,探讨番茄红素对其的干预作用。方法:30例MHD患者,随机分为对照组和试验组,各15例。对照组在患者透析时给予蔗糖铁注射液100 mg,2次/周,共10次,观察时间8周;试验组除蔗糖铁注射液使用外,同时口服番茄红素胶囊,2粒/次,2次/d。用药8周,观察时间8周,观察并比较两组患者治疗前及治疗8周后的血红蛋白(Hb)、红细胞比容(Hct)、血清铁(SI)、铁蛋白(SF)、转铁蛋白饱和度(TSAT)以及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-px)、丙二醛(MDA)等指标的变化。结果:两组患者治疗后SOD和GSH-px水平较治疗前均有显著下降(P<0.01);但是试验组下降幅度显著性小于对照组(P<0.01)。两组患者治疗后MDA水平较治疗前有显著性升高(P<0.01);但是试验组升高幅度显著性小于对照组(P<0.01)。治疗后两组血清MDA水平与SF呈正相关(P<0.01)。治疗后两组Hb、Hct、SI、SF、TSAT较治疗前均有显著性升高(P<0.01),并且两组升高幅度相似,无统计学差异。结论:静脉铁剂治疗加剧了MHD患者的氧化应激状态。番茄红素可减轻这种氧化应激状态。
Objective：To observe oxidative stress induced by intravenous iron and its prevention by lycopene in maintenance hemodialysis（MHD） patients. Methods：30 MHD patients were randomly divided into two groups：control group（ n = 15） and treatment group（n = 15）. In control group, the patients were treated with iron sucrose 100rag intravenously, during 10 consecutive hemodialysis sessions,twice a week for five weeks. In treatment group, in addition to intravenous iron, the patients were given lycopene, 2 # orally, twice a day for eight weeks. Their hemoglobin （ lib ）, hematocrit （ Hct ）, serum iron（SI）, serum ferritin（SF）, trans- ferring saturation（TAST） ,superoxide disrnutase （SOD）, glutathione peroxidase （ GSH - px） and malondialdehyde （MDA） levels were measured at pre- and post- treatment. Results：Compared with those in the pre- treatment,the levels of serum SOD and GSH - px in both groups decreased markedly（P〈0.01）, but the descent range of serum SOD and GSH- px in treatment group was less than those in control group（P〈0.01）.Compared with those at the pre- treatment,the levels of serum MDA in both groups were elevated significantly（ P 〈 0.01 ）. but the increarnent rate of MDA in treatment group was less than that in control group（ P 〈 0.01 ）. At post - treatment, the levels of serum MDA were positively correlated to the levels of SF in both groups （ P 〈 0.01 ）. Compared with those in the pre - treatment, the levels of lib, Hct, SI, SF, and TSAT increased significantly in both groups（ P 〈 0.01 ） at post - treatment. Moreover, the increarnent rates of them were not significantly different between both of groups. Conclusion： Intravenous iron therapy could induce aggravation of oxidative stress in MHD patients, which could be alleviated by lycopene.
出处
《中国中西医结合肾病杂志》
2008年第5期423-425,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
