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runx-2基因与牙发育 被引量：3

runx-2 and tooth development
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摘要 runx-2基因在牙的发育过程中发挥重要调控作用。下面就runx-2基因的结构特征及其在牙胚细胞的分化、牙体组织的形成和牙髓干细胞定向分化中所起作用作一综述。 Recent studies revealed unique functions for runx-2 in the differentiation of pluripotent mesenchymal cells into osteoblasts. This review provides the lately research advance about the structure of runx-2 gene, and the striking role of it during tooth development.
作者 文军 陆群 朱庆林
机构地区 第四军医大学口腔医院牙体牙髓病科
出处 《国际口腔医学杂志》 CAS 2008年第2期164-166,共3页 International Journal of Stomatology
基金 国家自然科学基金资助项目(30700943) 陕西省科学技术发展计划资助项目(2006K14-G10920)
关键词 runx-2 核心结合因子-α1 牙发育 牙髓干细胞 runx-2 core binding factor-α tooth development dental pulp stem cell
分类号 R78 [医药卫生—口腔医学]
  • 相关文献

参考文献20

  • 1[1]Chen S,Gu TT,Sreenath T,et al.Connect Tissue Res,2002,43(2/3):338-344.
  • 2[2]Fukuta Y,Totsuka M,Fukuta Y,et al.J Oral Sci,2001,43(2):85-89.
  • 3[3]Jiang H,Sodek J.Karsenty G,et al.Mech Dev,1999,81(1/2):169-173.
  • 4[4]Aberg T,Wang XP,Kim JH,et al.Dev Biol,2004,270(1):76-93.
  • 5[5]Aberg T.Cavender A,Gaikwad JS,et al.J Histochem Cytochem,2004,52(1):131-139.
  • 6[6]Wang XP,Aberg T.James MJ,et al.J Dent Res,2005,84(2):138-143.
  • 7[7]Yamashiro T.Aberg T,Levanon D,et al.Gene Expr Patterns,2002,2(1/2):109-112.
  • 8[8]Bronckers AL,Engelse MA,Cavender A,et al.Mech Dev,2001,101(1/2):255-258.
  • 9[9]Gaikwad JS,Hoffmann M,Cavender A,et al.Adv Dent Res,2001,15:19-24.
  • 10[10]Dhamija S,Krebsbach PH.J Biol Chem,2001,276(37):35159-35164.

二级参考文献17

  • 1Massague J,Wotton D.Transcriptional control by the TGF-beta/Smad signaling system[J].EMBO J,2000,19(8):1745-54.
  • 2Feng JQ,Luan X,Wallace J,et al.Genomic organization,chromosomal mapping,and promoter analysis of the mouse dentin sialophosphoprotein (Dspp) gene,which codes for both dentin sialoprotein and dentin phosphoprotein[J].J Biol Chem,1998,273(16):9457-64.
  • 3Chen S,Gu TT,Sreenath T,et al.Spatial expression of Cbfa1/Runx2 isoforms in teeth and characterization of binding sites in the DSPP gene[J].Connect Tissue Res 2002,43(2-3):338-344.
  • 4Lee KS,Kim HJ,Li QL,et al.Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2,and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12[J].Mol Cell Biol,2000,20(23):8783-92.
  • 5Ducy P,Zhang R,Geoffroy V,et al.Osf2/Cbfa1:a transcriptional activator of osteoblast differentiation[J].Cell,1997,89 (5):747-54.
  • 6Komori T,Yagi H,Nomura S,et al.Targeted disruption of Cbfa1 res μlts in a complete lack of bone formation owing to maturational arrest of osteoblasts[J].Cell,1997,89(5):755-764.
  • 7Otto F,Thornell AP,Crompton T,et al.Cbfa1,a candidate gene for cleidocranial dysplasia syndrome,is essential for osteoblast differentiation and bone development[J].Cell,1997,89(5):765-771.
  • 8Alliston T,Choy L,Ducy P,et al.TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation[J].EMBO J,2001,20 (9):2254-72.
  • 9Gaikwad JS,Hoffmann M,Cavender A,et al.Molecular insights into the lineage-specific determination of odontoblasts:the role of Cbfa1[J].Adv Dent Res,2001,15 (1):19-24.
  • 10MacDougall M,Unterbrink A,Carnes D,et al.Utilization of MO6-G3 immortalized odontoblast cells in studies regarding dentinogenesis[J].Adv Dent Res,2001,15(1):25-29.

共引文献2

同被引文献12

引证文献3

二级引证文献6

国际口腔医学杂志
2008年 第2期

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