摘要
2型糖尿病以葡萄糖和脂类的异常代谢为特征,部分归因于周缘组织的胰岛素抵抗。腺苷酸活化蛋白激酶(AMPK)是一种异源三聚体蛋白,由α、β和γ3个亚单位组成。AMPK在调节肌体能量代谢的平衡方面起总开关作用。在肌肉和肝脏中,AMPK的活化增强了葡萄糖的摄取、脂肪酸氧化作用和胰岛素敏感性,并且减少了葡萄糖、胆固醇和甘油三酯的产生。有研究表明,治疗2型糖尿病的一线药物二甲双胍和罗格列酮对机体代谢的影响部分通过AMPK途径。因此,AMPK及其信号通路有望成为治疗肥胖和2型糖尿病的新药理学靶点。
Type 2 diabetes is characterized by the abnormal me- tabolism of glucose and lipid, due in part to insulin resistance in peripheral tissues. The AMP activated protein kinase （AMPK） is a heterotrimeric protein consisting of ot catalytic subunit and β/γregulatory subunits. It acts as a master switch in regulating balance of the energy metabolism. In the muscle and liver ; the activated AMPK enhances glucose uptake, fatty acid oxidation and insulin sensitivity,and decreases production of glucose, cho-lesterol, and triglycerides. The recent finding suggests that the leading anti-diabetic drugs metformin and rosiglitazone regulate glucose metabolism partially through AMPK. These data suggest that AMPK is the potential pharmacological target for the treat- ment of type 2 diabetes.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2008年第5期580-583,共4页
Chinese Pharmacological Bulletin
基金
香港保健协会研究资助项目(NoHK20040906)
