摘要
目的:调查门诊中老年男性患者的前列腺特异性抗原(PSA)分布情况,分析规律,研究PSA检查在门诊筛查前列腺癌的意义。方法:患者血清PSA检查使用ELISA方法,所有患者都经过其他辅助检查确诊,用SPSS统计软件包进行相应的统计学处理。结果:在非前列腺疾病组、前列腺增生组和前列腺癌组tPSA≤4ng/ml各占87%、53%和17%;tPSA位于4～10ng/ml的患者各占10.6%、29%和16%;tPSA≥10ng/ml患者各占2.4%、18%、69%。将tPSA≤4ng/ml及tPSA位于4～10ng/ml按照fPSA/tPSA≤15%、15%～20%和>20%分为3部分,3组病例经统计学处理无显著差异。结论:门诊PSA筛查有利于发现和诊断前列腺癌,但发现的前列腺癌以晚期为主,提示PSA在中老年人群中普查的必要性,fPSA/tPSA在前列腺癌的鉴别诊断中的意义有待于进一步明确。
Objective： To investigate the distribution characteristics of serum prostate specific antigen （PSA） level in old male outpatients, find out some regularities, and study the significance of the PSA measurement in prostate carcinoma screening in outpatients. Methods： Serum PSA level were measured by ELISA method, all the diagnoses were confirmed by other auxiliary examinations. The distribution characteristics were evaluated by SPSS software package. Results： In patients without prostate disease group, benign prostate hyperplasia group, and prostate carcinoma group, the total PSA level ≤ 4 ng/ml respectively accounted for 87%, 53% and 17%. Total PSA between 4 ng/ml and 10 ng/ml respectively accounted for 10.6%, 29%,and 16%. Total PSA ≥ 10ng/ml respectively accounted for 2.4%, 18%, and 69%. Dividing the patients whose tPSA level ≤ 4 ng/ml and between 4 and 10 ng/ml into three groups respectively according to the proportion of free PSA to total PSA, the results showed that there were not significant differences among lower than 15%, 15%-20%, and higher than 20% groups. Conclusion：Total PSA measurement is very effective in the diagnosis of prostate carcinoma, so screening tPSA in senium male outpatients is necessary and helpful. When the tPSA level is lower than 4 ng/ml or between 4 and 10 ng/ml, fPSA/tPSA ratio is not as helpful as other authors reported in differential diagnosis of prostate patients.
出处
《天津医科大学学报》
2008年第2期197-199,共3页
Journal of Tianjin Medical University
关键词
老年男性
前列腺特异性抗原
前列腺癌
门诊
Senium male outpatients
Serum PSA level
Prostate carcinoma
Outpatient
