摘要
目的:探讨四逆散对失眠大鼠睡眠时相的影响,为四逆散改善睡眠的作用提供实验依据。方法:采用电刺激诱导大鼠失眠,利用脑电图描记的方法,观察给予四逆散水煎液后失眠大鼠睡眠时相的变化。结果:四逆散水煎液可显著延长失眠大鼠的总睡眠时间(TST),在睡眠时相上主要表现为延长SWS2和REMS,对SWS1没有显著的影响,并使觉醒时间(W)显著减少。结论:四逆散能延长失眠大鼠的SWS2和REMS。
Objective: To study the effects of Sinisan on the sleep phase of insomnia rats.Methods:Adopting the experimental method of PSG and electric stimulation to tempt the insomnia of rats.Observing the effect of the Sinisan on the sleep phase of insomnia rats.Results: The results showed that Sinisan could obviously decrease the duration of W and increase TST,primarily prolong SWS2 and REMS.Conclusion:The Sinisan can prolong SWS2 and REMS of insomnian rats.
出处
《中国医药导报》
CAS
2008年第15期19-19,36,共2页
China Medical Herald
基金
黑龙江省科学技术计划项目项目编号:20010101-00