摘要
目的探讨女性社区获得性尿路感染(CAUTI)病原菌特点、趋势及早期高效的筛查方法。方法结合尿沉渣超高倍多相显微镜镜检法和清洁中段尿培养,分析1008例南京地区女性CAUTI患者病原菌分布的特点及耐药情况。结果CAUTI病原菌革兰氏阴性杆菌占75.0%(其中大肠埃希菌42.8%),药敏结果提示大肠杆菌对阿莫西林/克拉维酸(24.7%)、哌拉西林/他唑巴坦(4.5%)、头孢哌酮/舒巴坦(1.1%)和阿米卡星(13.5%)耐药率低,未见对美罗培南和亚胺培南耐药。超高倍多相显微镜镜检结果中白细胞及细菌数越多,中段尿培养的阳性率越高。结论大肠杆菌仍是南京地区女性CAUTI的主要致病菌;超高倍多相显微镜镜检对CAUTI早期诊断有很高的价值。
Objective To investigate the new trend of etiology and antimicrobial resistance of pathogens from community-acquired urinary tract infection （CAUTI） in female in Nanjing for finding out an efficient method for the initial screening of CAUTI. Methods Distribution and resistance of pathogens causing CAUTI at Nanjing First Hospital in China from 2004 to 2007 were analyzed by multimedia microscopy diagnostic-instrument detection and the culture of mid-stream urine. Results Gram-negative bacilli accounted for 75%, with 42. 8% of E. Coli. Resistance rate of E. Coli to amoxicillin/clavulate （24. 7 %）, piperacillin/tazobactam （4. 5 %）, cefoperazone/sulbactam （1.1%） and amikacin （13.5%） were significantly lower than that of the others. No resistance of E. Coli to meropenem and imipenem was found. There was a good correlation between multimedia microscopy diagnostic-instrument detection and culture. Conclusion E. Coli is still the major pathogen in CAUTI. Phase-contrast microscopic multimedia microscopy diagnostic-instrument detection is an efficient method for the initial screening of CAUTI.
出处
《江苏医药》
CAS
CSCD
北大核心
2008年第6期571-573,F0002,共4页
Jiangsu Medical Journal
关键词
尿路感染
病原菌
Urinary tract infection
Pathogen
