摘要
目的观察D2-40、calretinin及HBME-1在浆膜腔积液间皮和转移性癌细胞中的表达,评价其用于鉴别诊断的价值。方法用细胞块技术对87例浆膜腔积液标本进行免疫组化检测,观察D2-40、calretinin和HBME-1在癌细胞和间皮细胞中的表达。结果D2-40、calretinin和HBME-1标记间皮细胞的敏感度分别为48.1%、81.0%、77.2%,特异度分别为90.2%、69.5%、61.0%。三者联合的敏感度和特异度分别为70.9%和81.7%。三者标记卵巢癌腹水间皮细胞的特异性都不高。结论D2-40、calretinin和HBME-1合用可辅助鉴别诊断转移性癌与间皮。
Purpose To evaluate the value of D2-40, calretinin and HBME-1 in identifying the mesothelial cells in body cavity effusions. Methods 87 effusion specimens were assessed by immunohistochemical analysis in cell blocks. Results The sensitivity rates of D2-40, calretinin and HBME-1 were 48. 1% , 81.0% and 77.2% , respectively. The specificity rates were 90. 2% , 69.5% , 61.0%. And the combined sensitivity and specificity were 70. 9% and 81.7% , respectively. The specificity of all the three markers in identifying the mesothelial cells in ovarian cancer induced ascites was not high. Conclusion Combined detection of D2-40, calretinin and HBME-1 is an accessory method for differentiation between metastasis cancer and mesothelial cells.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2008年第3期337-340,共4页
Chinese Journal of Clinical and Experimental Pathology
