3ILLUM L.Nasal drug delivery-possibilities,problems and solutions[J].Journal of Controlled Release,2003,87(1-3):187-198.
4KAO H D,TRABOULSI A,ITOH S,et al.Enhancement of the systemic and CNS specific delivery of L-dopa by the nasal administration of its water soluble prodrugs[J].Pharmaceutical Research,2000,17 (8):978-984.
5SAKANE T,YAMASHITA S,YATA N,et al.Transnasal delivery of 5-fluorouracil to the brain in the rat[J].Journal of Drug Targeting,1999,7(3):233-240.
6CHOU K J,DONOVAN M D.The distribution of local anesthetics into the CSF following intranasal administration[J].International Journal of Pharmaceutics,1998,168(2):137-145.
7LIU X F,FAWCETT J R,THORNE R G,et al.Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion[J].Neuroscience Letters,2001,308(2):91-94.
10ZHENQI S,QIZHI ZH,XINGUO J.Pharmacokinetic behavior in plasma,cerebros pinal fluid and cerebral cortex after intranasal administration of hydrochloride meptazinol[J].Life Sciences,2005,77:2574-2583.
7Maitani Y, Asano S, Takahashi S. et al. Permeability of insulin entrapped in liposome through the nasal mucosa of rabbits[ J]. Chem pharm Bull, 1992,40(6): 1 569- 1 572.
8Vyas SP, Goswami SK, Singh R. Liposomes - based nasal delivery system of nifedipine: development and characterization [J]. Int J Pharm, 1995, 118(1):23 -27.
9Kozo Takayama, Tsuneji Nagai, Kazunori Muramatsu. The Relationship Between the Rigidity of the Liposomal Membrane and the Absorption of Insulin After Nasal Administration of Liposomes Modified with an Enhancer Containing Insulin in Rabbits[J ]. Drug Dev Ind Pharm. 1999, 25 (10):1 099 - 1 105.
10Ahn BN, Kim SK, Shim CK. Proliposomes as an intranasal dosage from for the sustained delivery of propranolol[J]. J Control Release, 1995, 34:203 - 205.