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停服华法林对风湿性心脏瓣膜病伴心房颤动患者血浆纤维蛋白原和血栓栓塞的影响 被引量:2

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摘要 目的探讨持续口服、停止口服及未服华法林抗凝治疗对风湿性心脏瓣膜病伴房颤患者血浆纤维蛋白原(Fg)含量和血栓栓塞发生率的影响。方法将确诊风湿性心脏瓣膜病伴心房颤动患者92例,根据华法林口服情况分为三组:持续口服华法林组、停止口服华法林组及未服华法林组。分别测定外周静脉血浆纤维蛋白原(Fg)含量及观察各组血栓栓塞发生率。结果停止口服华法林组血浆Fg含量为(413±142)mg/dl,显著高于持续口服华法林组(286±48)mg/dl,P<0.01及未服华法林组(388±124)mg/dl,P<0.05;持续口服华法林组与未服华法林组血浆Fg含量差异有统计学意义,P<0.01。停止口服华法林组血栓栓塞发生率为(19.0%)明显高于持续口服华法林组(3.3%)和未服华法林组(7.3%),P<0.01;持续口服华法林组与未服华法林组比较差异有统计学意义,P<0.05。结论风湿性心脏瓣膜病伴心房颤动患者停止口服华法林治疗后血浆纤维蛋白原(Fg)含量升高,致血栓栓塞危险明显超过未服华法林及持续口服华法林患者。
作者 聂晶 范立红
出处 《临床医学》 CAS 2008年第5期34-35,共2页 Clinical Medicine
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