摘要
目的:研究芹菜素镇痛消炎作用。方法:以小鼠为实验对象,灌胃法芹菜素给药。阿司匹林为阳性对照药,以醋酸所致扭体反应为疼痛指标。以二甲苯所致小鼠耳廓肿胀为炎症指标。结果:本品高低剂量组均有镇痛作用,芹菜素高剂量组与阿司匹林组相当。各剂量组均有明显的消炎作用,芹菜素高剂量优于阿司匹林。结论:芹菜素具有镇痛消炎作用,提示芹菜素可开发成镇痛消炎新药,挖掘其临床应用价值,为广大患者造福。
Objective：Effects of Apigenin on anti-inflammatory and analgesic were studied in mice. Methods ： pains in writhing model; ear edema of mice.Results ： Apigenin had evident inhibition in the proliferation of the swelling of mice ears induced by xylene （ P〈0.01 ）; the results of analgesic experiments showed that Lilium lancifolium Thunb. remarkably inhibited pains in writhing model by acetic acid glacial （ P〈0.01 ） .Conclusion ： Apigenin had the anti-inflammatory and analgesic effects.
出处
《辽宁中医药大学学报》
CAS
2008年第7期145-146,共2页
Journal of Liaoning University of Traditional Chinese Medicine
基金
南通大学自然科学研究项目资助项目(05Z030)
关键词
芹菜素
消炎
镇痛
扭体反应实验
耳廓肿胀实验
Apigenin
anti-inflammatory
analgesic
body writhing test
ear swelling test
