摘要
目的观察异丙酚靶控输注（TCI）麻醉与异丙酚复合咪唑安定麻醉用于腹腔镜胆囊切除术（LC）中对全身麻醉质量的影响。方法选择60例择期行LC的患者随机分成异丙酚靶控输注组（A组,30例）和异丙酚复合咪唑安定组（B组,30例）。A组采用血浆靶控浓度4μg/ml异丙酚诱导,术中用3～3.5μg/ml维持。B组采用0.1mg/kg咪唑安定、1mg/kg异丙酚诱导,术中采用10-8-6mg/（kg·h）方案输注异丙酚维持。术中持续监测患者SBP、DBP、HR,观察麻醉时间、拔管时间、苏醒质量、苏醒表现（烦躁、恶心、呕吐）情况。结果两组患者诱导3min后SBP、DBP、HR低于术前（P〈0.05）,气腹10min后SBP、DBP、HR高于诱导前、后3min及插管后（P〈0.05）,但两组间无差异。A组拔管时间短于B组（P〈0.05）,苏醒质量好于B组（P〈0.05）。结论异丙酚靶控输注麻醉用于LC比咪唑安定复合异丙酚麻醉好。
Objective To study the qualitative of general anesthesia maintained by propofol target-controlled infusion（TCI） or by propofol combined with midazolam in laparoscopic cholecystectomy（ LC）. Methods Sixty patients scheduled for LC were randomized to t two groups： TCI group （ A-group, n = 30）, propofol combined with midazolam（ B-group, n = 30）. The patients in A-group were given TCI with the target concentration 4μg/ml during induction and 3 - 3.5μg/ml during maintenance. And in B-group were accepted 0. 1 mg/kg midazolam, 1mg/kg propofol during induction and infused 10-8-6mg/kg, h propofol during maintenance. SBP, DBP and HR were monitored continuously during operation. The time of anesthesia and extubation, the qualitative and the representation （agitation, nausea, vomit ） of recovery were recorede in operation. Results The vital sings of patients in two groups after 3-min induction were lower than those before induction（ P 〈 0.05） .The vital sings of patients in two groups after 10-min aeroperitonia were higher than those before induction,after 3-min induction and intubation（ P 〈 0.05 ）. But there have no difference between two groups. The time of extubation in A-group was shorter than B-group （ P 〈 0. 05 ）. The qualitative of consciousness of A-group was better than B-group （ P 〈 0. 05 ）. Conclusion The anesthesia maintenance by propofol TCI in LC is better than midazolam combined with propofol.
出处
《四川医学》
CAS
2008年第6期669-671,共3页
Sichuan Medical Journal
