摘要
目的探讨冻干重组人脑利钠肽(rhBNP)治疗急性心力衰竭的疗效和安全性。方法32例急性心力衰竭患者随机分为两组,rhBNP组(n=15):先以rhBNP 1.5μg/kg静脉冲击后,再以0.007 5μg.kg-1.min-1连续静脉滴注;对照组(n=17)静脉持续泵注硝普钠。记录两组治疗前后呼吸困难程度、全身情况、左室射血分数(EF)和E/A指数等。rhBNP的安全性评估采用治疗药前后定期测量血压、心率,复查血电解质及肾功能,并对所有不良事件进行记录。结果治疗72h后rhBNP组呼吸闲难和临床状况好转率优于对照组(P<0.05);rhBNP组治疗后左室收缩舒张功能指数较对照组明显改善(P<0.05),rhBNP组未发生药物相关的不良事件。结论rhBNP能改善急性心力衰竭患者的呼吸困难程度和临床状况,心脏超声提示心脏收缩舒张功能明显改善,治疗安全可靠。
Objective To study the effficacy and safety of domestic recombinant human brain natriuretic peptide（rhBNP）for treating acute heart failure. Methods Thirty patients with acute heart failure were randomly divided into rhBNP group and control group. The rhBNP group received rhBNP 1.5μg/kg by bolus intravenous injection followed by 0. 007 5μg · kg^-1·min^-1 for continuous intravenous infusion. The control group was used with lasting vein pump of sodium nitroprusside. The changes in degree of dyspnea,general physical condition,left ventricular ejection fraction（LVEF） and index of E/A were recorded before and after treatment. The changes in BP, HR, urinary output, SCr, BNP, and left ventricular ejection fraction（LVEF） were compared before and after treatment. Blood pressure, heart rate, electrolytes, and renal function and improvement in symptoms and signs were evaluated and adverse events were documented. Results Dyspnea and symptom improvements were more significant in rhBNP group compared with control group after 72h treatment （P〈0.05）. The levels of index of left ventricular contraction and relaxation functions in rhBNP group were higher than those in control group before and after treatment（P〉0.05）. It demonstrated good tolerance in the treatment of acute heart failure. No severe adverse drug reactions were observed in rhBNP group. Conclusion rhBNP is superior to sodium nitroprusside for improving dyspnea and symptoms in the patients with acute heart failure, rhBNP can relieve the clinical symptoms of acute heart failure. The systolic and diastolic function of heart in the patients had obvious improvement by echocardiographic evaluation. The safety of rhBNP was comparable to nitroglycerin in treating acute heart failure.
出处
《重庆医学》
CAS
CSCD
2008年第13期1469-1470,共2页
Chongqing medicine
关键词
急性心力衰竭
重组人脑利钠肽
治疗
acute heart failure
recombinant human brain natriuretie peptide
treatment
