摘要
【目的】探讨合并膀胱出口梗阻的前列腺癌的综合治疗。【方法】1999年1月至2007年12月采用以双侧睾丸切除术（去势术）、经尿道前列腺电切术（TURP）及间歇雄激素阻断等综合治疗方法治疗合并膀胱出口梗阻的前列腺癌265例。【结果】所有手术均成功,无阴囊切口感染病例。平均住院（7.1±2.8）d。术后3个月复查尿流动力学,最大尿流速（MFR）15.5～21.0mL/s,平均16.5mL/s。残余尿25～85mL,平均40mL。国际前列腺症状评分（IPSS）降为（8.6±1.5）分;185例前列腺特异性抗原（PSA）0～4ng/mL,63例PSA为4～10ng/mL,17例PSA〉10ng/mL。随访6～24个月,其中12例分别于术后6～14个月死于前列腺癌,18例术后10个月死于其他疾病,其余患者带癌存活。【结论】合并膀胱出口梗阻的前列腺癌采用TURP、去势术和间歇雄激素阻断的综合治疗具有创伤小、恢复快等优点,且能延长患者生存期及提高患者的生存质量,值得推广应用。
[Objective]To investigate combined therapy of prostatic carcinoma complicated with bladder outlet obstruction. [Methods] From January 1999 to December 2007, 265 cases of prostatic carcinoma with bladder outlet obstruction were treated with bilateral orchidectomy combined with transurethral resection of prostate（TURP） and intermittent male hormone blockage. [Results]All the operations succeeded. There was no case of infection. The mean days in hospital were 7.1±2.8. The max flow rate was 15.5±21.0mL/s 3 months after TURP. The residual urine was 25～85mL. IPSS was 8.6±1.5. PSA was 0～4ng/mL in 185 cases, 4～10ng/mL in 63 cases and more than 10ng/mL in 17 cases. The follow-up was 6～24 months. Twelve cases died of prostatic carcinoma and 18 cases died of other diseases. The others survived with carcinoma. [Conclusion] Combined therapy, which includes bilateral orchidectomy, TURP and intermittent male hormone blockage, for prostatic carcinoma with bladder outlet obstruction has advantages of minimal trauma and rapid recovery. It can prolong life span and improve the quality of life, and be worth of wide application.
出处
《医学临床研究》
CAS
2008年第6期977-979,共3页
Journal of Clinical Research
