摘要
[目的]观察缩宫素与卡前列素治疗有出血高危因素的产妇剖宫产术中、术后出血的有效性与安全性。[方法]对123例具有出血高危因素的产妇在剖宫产术中分别应用缩宫素、卡前列素、缩宫素加卡前列素,计算3组术中、术后2h出血量及总出血量并观察3组的副反应。[结果]3组产妇术中总出血量分别为:缩宫素组(625±315)ml,卡前列素组(489±289)ml,缩宫素加卡前列素组(439±225)ml,缩宫素组分别与卡前列素组、缩宫素加卡前列素组比较,差异有统计学意义(P﹤0.05,P﹤0.05);缩宫素加卡前列素组与卡前列素组比较,差异无统计学意义(P﹥0.05)。副反应发生率缩宫素组为4.9%,卡前列素组8.9%,缩宫素加卡前列素组8.1%,,以呕吐为常见,短时间好转。[结论]卡前列素用于有出血高危因素产妇的剖宫产术可明显减少术中、术后出血量,与缩宫素联合应用效果更好。
[Objective] To observe the effect and safety of oxytoein and earboprost on prevention of postpartum hemorrhage during cesarean section and after cesarean section in high risk pregnant women. [ Methods] Oxytocin, carboprost and oxytocin plus carboprost were used in cesarean section for 123 pregnant women with high risk factor as hemorrhage, the amount of bleeding during the operation and within 2-hour after delivery were measured and the side effect of each group was observed. [Results] The amount of bleeding during cesarean section in oxytocin group （O） was （625± 315） ml, in earboprost group （C） was （489 ± 289） rnl, and in oxytocin plus earboprost group （O＋C） was （439±225） ml. There was a significant difference between groups O and C （P 〈 0.05）. There was an extremely significant difference between groups O and O＋C （P〈 0.05）. There was no significant difference between groups H and O＋C （P 〉 0.05 ）. The incidence of side effects in the three groups was 4.9%, 8.9% and 4.9%, respectively. Vomiting was frequently seen in the three groups but recovered soon without treatment. [Conclusion] Carboprost can reduce the amount of bleeding during the cesarean section in pregnant women with high risk factor as hemorrhage significantly and can be used with oxytocin to obtain better effects in preventing hemorrhage during and after delivery.
出处
《现代预防医学》
CAS
北大核心
2008年第14期2802-2803,共2页
Modern Preventive Medicine
关键词
产后出血
宫缩乏力
缩宫素
卡前列素
Postpartum hemorrhage
Uterine inertia
Oxytocin
Carboprost
