摘要
为了观察促肝细胞生长素（pHGF）抗内毒素／感染性休克的治疗作用，在与对照组（32例）进行相同的常规抢救和治疗的基础上，观察组（36例）加用pHGF。结果：观察组死亡率16．67％（6／36）较对照组死亡率31．25％（10／32）明显下降，P＜0．01；休克状态改善所需时间明显缩短，P＜0．01。结论：PHGF抗内毒素／感染性休克的作用是通过降低肿瘤坏死因子（TNF）水平而达到的，为抗内毒素／感染性休克提供了新途径。
Aim: To investigate the effect of promoting hepatocyte growth factor (pHGF) on antiendotoximia or anti -infective shock. Methods: Thirty-six cases of endotoximia or infective shock were treated intravenously with pHGF. The effect of pHGF was compared with that of the controlled (thirty-two cases) .Results: The mortality was lower in pHGF group (16. 67%, 6/36) than in control group (31.25 %, 10/32), p<0. 01; and the recovery time from shock was shorter in pHGF group than in control group (p<0. 01 ). Conclusion: The results suggested that the effect of pHGF was introduced by decreasing the level of tumour necrosis factor, and it is a new therapy to endotoximia or infective shock.
出处
《急诊医学》
CSCD
1997年第5期262-263,共2页
关键词
促肝细胞生长素
内毒素
感染性休克
Promoting hepatocyte growth factor Endotoximia/infective shock Tumour necrosis factor
