摘要
笔者就输注国产ＩＶＩＧ后传播ＨＣＶ的危险性作了研究。２９名有ＩＶＩＧ应用指针的病儿，输注经加热法灭活病毒的ＩＶＩＧ后１周、２周、１月，抗－ＨＣＶ阳性率分别为８３．３％、４５．５％、４．６％，３个月后全部转阴，显示抗－ＨＣＶ随输注ＩＶＩＧ后时间延长而转阴。随机抽取１１名输注ＩＶＩＧ后抗－ＨＣＶ阳性病儿的２４份系列血标本，用ｎｅｓｔ－ＰＣＲ检测ＨＣＶ－ＲＮＡ，无阳性发现。检则１０份ＩＶＩＧ中抗－ＨＣＶ均阳性，抗－ＨＣＶ滴度１∶１６，抽取６份ＩＶＩＧ，ＨＣＶ－ＲＮＡ阴性。经３个月～１年观察，所有病例无肝炎的临床症状和体征，结果支持：用于本研究的国产ＩＶＩＧ输注可被动输入抗－ＨＣＶ，但不传播ＨＣＶ。
The risk of HCV transmission after infusion of intravenous immunoglobulin was studied.Subjected to inactivation of virus in it by heating method,the IVIG was infused in 29 child patients with indication for use of IVIG,whose positive rate of HCVAb test was 83.3%,45.5% and 4.6%,respectively in one week,two weeks and one month after infusion of IVIG,but in three months,they all have shown negative results,indicating that the HCVAb test results would be translated into negative ones as the time was prolonged after infusion of IVIG.24 serial sera samples of 11 child patients,whose HCVAb tests were positive after infusion of IVIG,were taken at random and tested for HCVRNA by nestPCR,as a result,there were no any positive results.All of 10 samples of IVIG tested for HCVAb showed positive results,and HCVAb titer was 1∶16.All of 6 samples tested for HCVRNA by nestPCR showed negative results.And all patients haven't shown any clinical symptoms and physical signs of hepatitis during the observation period from 3 months to 1 year.The result supported that infusion of domestically produced IVIG which was used for this study could bring HCVAb in patients,but did not make the HCV transmitted.
出处
《中国输血杂志》
CAS
CSCD
北大核心
1997年第4期179-180,共2页
Chinese Journal of Blood Transfusion
