摘要
目的:优化三七总皂苷口腔崩解片的处方。方法:以甘露醇、微晶纤维素和乳糖为辅料,采用多元回归方程、效应曲面和等高线图方法考察了压力变化、处方配比与口腔崩解片抗张强度和崩解时间的关系,并优化出最佳处方。结果:按优选处方制得的口腔崩解片,具有一定硬度,在口腔中30 s内能迅速崩解,且口感良好。结论:三七总皂苷口腔崩解片达到了设计要求,此方法可很好的应用于处方筛选。
Objective： To optimize the formulation of panax notoginsenoside orally fast disintegrating tablets. Method： Mannitol, microcrystalline cellulose （PH 102） and lactose 80 were used as diluent. A polynomial regression algorithm was used to evaluate the relationship between the controlling factor, compacting pressure and diluent ratio, and disintegration time, tensile strength of tablets. Optimum formulation and process parameters could be determined by contrast the contour plot of tensile strength to that of disintegration time. Result： The disintegration time and tensile strength of panax notoginsenoside oral disintegrating tablets were good, and the taste was satisfactory. Conclusion： Panax notoginsenoside oral disintegrating tablets achieve the goal of design and this method can be fairly used in formulation screening.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2008年第14期1676-1680,共5页
China Journal of Chinese Materia Medica
基金
上海市优秀青年教师培养项目
关键词
三七总皂苷
口腔崩解片
效应曲面
panax notoginsenoside
oral disintegrating tablets
response surface
