摘要
目的研究宽叶荨麻抗类风湿性关节炎的药理作用,为宽叶荨麻的开发利用提供实验依据。方法将45只大鼠随机分为空白组,模型组,阳性药(雷公藤)组,宽叶荨麻水提物高、中、低浓度组,宽叶荨麻醇提物高、中、低浓度组,通过佐剂性关节炎模型来观察大鼠体重、原发侧和继发侧足跖肿胀度以及关节炎指数的变化。结果与空白组相比,注射弗氏完全佐剂的各组大鼠足跖可见明显肿胀。与模型组相比,宽叶荨麻水提物和醇提物高、中、低浓度组可以不同程度的减轻大鼠原发侧和继发侧足跖肿胀度以及关节炎指数。结论宽叶荨麻水提物高浓度组对大鼠类风湿性关节炎的抑制作用最强,优于阳性药(雷公藤)组,在治疗类风湿性关节炎方面宽叶荨麻具有进一步研究和开发的价值。
Objective To study the pharmacological effects of U. laetevirens Maxim. （UL） on rheumatoid arthritis and offer experimental basis for its exploitation and utilization. Methods 45 rats were divided randomly into 9 groups： blank group, model group, masculine group （tripterygium glycosides）, low, medium, high dosage groups of UL aqueous extracts, low, medimn, high dosage groups of UL ethanol extracts. After the model of arthritis induced by adjuvant was established in rats, the body weight of rats, the swelling of primary and secondary side, and the change of arthritis index were observed. Results Compared with the blank group, the rats that were injected Freund＇s adjuvant Complete （CFA） swelled obviously. Aqueous extracts and ethanol extracts of UL low, medium, high dosage groups could inhibit the swelling of primary and secondary side and arthritis index in different extent, as compared with model group. Conclusion UL aqueous extracts with high dosage have the inhibitory action on rheumatoid arthritis, and surpass masculine group （Tripterygium Glycosides）. U. laetevirens Maxim. is worthy to be researched and exploited in treating rheumatoid arthritis.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第4期777-779,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金资助项目(No.30572317)
关键词
宽叶荨麻
类风湿性关节炎
弗氏完全佐剂
U. laetevirens Maxim. （UL）, Rheumatoid Arthritis（RA）, Freund＇s adjuvant Complete （CFA）
