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中国汉族原发性高血压患者G蛋白β3亚单位825C/T多态性Meta分析 被引量：5

Meta-analysis on G-protein β3 Subunit 825C/T Polymorphism in Han Chinese Patients with Essential Hypertension
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摘要 目的探讨我国汉族人群G蛋白β3亚单位(GNF3)基因825C/T多态性与原发性高血压之间的联系。方法检索国内有关GNF3基因825C/T多态性与原发性高血压关系的文献,进行Meta分析。结果以CC基因型为暴露因素,CT/TT基因型合并为非暴露因素,合并OR值为0.79,95%CI为(0.66,0.94),P<0.01;以TT基因型为暴露因素,CT/CC基因型合并为非暴露因素,合并OR值为1.14,95%CI为(0.93,1.14),P>0.05。结论我国汉族人群GNF3基因825C/T多态性与原发性高血压存在关联,CC基因型可能是原发性高血压的保护因素。 Objective To study the relationship of 825C/T polymorphism of G - protein β3 subunit gene extron 10 to essential hypertension （EH） in Han Chinese population by meta - analysis. Methods Pooled OR valUe and OR 95% CI were calculated to investigate relationship of GNF3 825 C/T to essential hypertension by searching domestic and international literatures, and quantitative assessment was performed by Meta - analysis on RevMan 4. 2 software. Results Taking CC genotypes as exposed factors, CT/TT genotypes merged into non - exposed factors, pooled OR value = 0.79, and 95% CI （0. 66, 0. 94 ） （ P 〈 0.01 ） ;TT genotypes as exposed factors, CT/CC genotypes merged into non - exposed factors, pooled OR value = 1.14, and 95% CI （0. 93, 1.14） （ P 〉 0. 05 ）. Condusion There is a correlation between GNF3 gene 825 C/T polymorphism and essential hypertension in Han Chinese population. CC genotypes may be the protective factors of essential hypertension.
作者 付凌雨 金辉 时玥 时景璞
机构地区 中国医科大学附属第一医院临床流行病教研室 中国医科大学附属第二医院临床药理教研室 中国医科大学
出处 《中国全科医学》 CAS CSCD 2008年第16期1439-1441,共3页 Chinese General Practice
关键词 高血压 单核苷酸多态 META分析 Hypertension Single nucleotidc polymorphism Meta analysis
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献18

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二级参考文献104

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中国全科医学
2008年 第16期

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