摘要
目的:探讨小剂量红霉素口服和静脉给药治疗新生儿喂养不耐受的疗效差别。方法:将符合新生儿喂养不耐受诊断标准的76例患儿分为两组各38例,两组均给予治疗原发病、对症治疗和补充水电解质平衡的常规治疗,口服组和静脉给药组均在此基础上加用小剂量红霉素[3～5mg/(kg.d)]口服或静脉滴注,10d为一疗程,比较两组疗效、转归和不良反应。结果:口服组和静脉给药组总有效率为86.8%和92.1%,每日喂奶量分别为(125±28)mL/kg和(123±30)mL/kg,体重增加0.35(0.14～0.58)kg和0.34(0.16～0.55)kg,上述指标比较差异均无统计学意义(P>0.05)。两组未见明显不良反应发生。结论:小剂量红霉素口服或静脉滴注对新生儿喂养不耐受疗效相似,口服方便。
Objective： To study the therapeutic effective difference between oral erythromycin and intravenous erythromycin. Methods： Seventy six children were divided into two groups with 38 case in each. Both groups accepted the same treatment and only the routes of administration for erythromycin were different （orally and intravenously, respectively）. Results： No difference in daily milk intake, gain in body weight and the total curative rate was observed （the oral group： 125 ±28 mL · kg^-1 · d^-1 , 0.35 kg, 86.8% ; the intravenous group ： 123 ± 30 mL ·~ kg^-1 · d^-1, 0.34 kg, 92.1%, all P 〉 0.05 ）. Conclusions： Though the effects of both administration routes are equivalent, oral erythromycin is more convenient and worth utilizing.
出处
《儿科药学杂志》
CAS
2008年第4期39-40,共2页
Journal of Pediatric Pharmacy
关键词
红霉素
新生儿
喂养不耐受
Erythromycin
Neonates
Feeding intolerance
