摘要
目的探讨凋亡抑制蛋白生存素(survivin)和缺氧诱导因子-1α(HIF-1α)在人肝细胞癌组织中的表达及相关性,分析其与肝细胞癌转移复发的关系。方法应用免疫组化S-P法检测80例肝细胞癌组织和癌旁组织中survivivn和HIF-1α蛋白的表达情况。结果80例肝细胞癌组织中survivivn和HIF-1α蛋白表达的阳性率显著高于癌旁组织(P<0.05),两者的表达与门脉癌栓、术后复发、肝外转移、肿瘤大小、肿瘤分化程度表达密切相关,HIF-1α的表达还与临床分期有关(P<0.05)。survivivn和HIF-1α的表达有显著相关性(r=0.349,P=0.001)。结论survivivn和HIF-1α与肝细胞癌侵袭转移的发生有密切关系。
Objective To investigate the expression of survivin and HIF-1α in in hepatocellular carcinoma（HCC） and its correlation with metastasis and recurrence. Methods Immunohistochemisty was employed to examine the expression of survivin and HIF-1α in 80 specimens of HCC tissues and 80 normal adjacent liver tissues. Results The positive rates of survivin and HIF-1α proteins in tumor tissues were significantly increased compared with those in adjacent liver tissues（P〈 0.05）. The expression of survivin and HIF-1α was significantly correlated with the tumor size, differentiation,portal vein cancerous thrombi,extrahepatic metastasis and recurrence. Furthermore,the expression of HIF-1α was also correlated with the clinical stages（P〈0.05）. There was a positive relationship of survivivn with HIF-1α（r=0. 349,P=0. 001）. Conclusion Both survivivn and HIF-1α are significantly related to the invasion and the metastasis of HCC.
出处
《实用肿瘤杂志》
CAS
2008年第4期331-335,共5页
Journal of Practical Oncology
基金
广西医疗卫生重点科研基金资助项目(桂卫重200612)
