摘要
NOD/SCID(非肥胖糖尿病/重症联合免疫缺陷)小鼠是在SCID(重症联合免疫缺陷)小鼠的基础上与非肥胖性糖尿病小鼠(NOD/Lt)品系回交的免疫缺陷鼠。NOD/SCID小鼠既有先天免疫缺陷,又有T和B淋巴细胞缺乏,各种肿瘤细胞可以植入,且较少发生排斥反应及移植物抗宿主病(GVHD),所以NOD/SCID小鼠逐渐成为血液学实验研究的有用工具。本文从NOD/SCID小鼠的生物学特性及其在建立人类白血病模型、干细胞移植、药物研究及NOD/SCID小鼠应用中存在的不足和改良等方面综合述评。
NOD/SCID （non-obese diabetic/severe combined immunodeficient） mice are immune deficient mice which are made by backcross of severe combined immunodeficient mice with non-obese diabetic mice strains. NOD/ SCID mice are both innate immune deficiencies and lack of T and B lymphocytes. Various tumor cells can be implanted in this kind of mice, the rejection and graft-versus-host disease （GVHD） occur fewer. Therefore, NOD/SCID mice gradually become a useful tool for the study on Experimental Hematology. This paper comprehensively reviews the biological characteristics of NOD/SCID mice, the establishment of human leukemia model , stem cell transplantation, drug research, deficiency and improvement of NOD/SCID mice in applieation for study.
出处
《中国实验血液学杂志》
CAS
CSCD
2008年第4期964-968,共5页
Journal of Experimental Hematology
基金
国家自然科学基金项目(编号30672743)
天津市应用基础研究项目(编号07JCYBJC11500)
