摘要
低氧是恶性肿瘤微环境的特征之一,胃癌低氧状态能促进肿瘤血管生成、抑制肿瘤细胞凋亡、影响细胞周期和增殖、增加放化疗及手术的抵抗性,使肿瘤对放化疗的疗效明显下降,并且促进肿瘤的侵袭和远处转移.通过体内氧电极测定、放射自显影、核磁影像技术等方法能够检测胃癌肿瘤的低氧微环境.采用吸入高压氧、carbogen或ARCON气体、给予缺氧细胞放射增敏剂等方法能提高肿瘤的放疗疗效.虽然胃癌肿瘤的低氧微环境对其治疗产生了一定影响,但其低氧微环境也为临床治疗提供了新的治疗方法,使胃癌低氧靶向治疗成为可能.因此,针对肿瘤低氧的低氧标记药物、HIF-1抑制剂、HIF-1基因治疗等将成为今后的研究热点.
Tumor hypoxia is a characteristic in many solid tumors. It has been demonstrated that hypoxia in gastric cancer could promote tumor microvessels angiogenesis, affect tumor cell apoptosis, regulate cell cycle, decrease the therapeutic efficacy of radiotherapy, surgery and some forms of chemotherapy, and promote tumor invasion and metastasis. Using oxygen electrodes, radiological and nuclear medical imaging techniques we could assess the tumor oxygenation status. The use of hyperbaric oxygen, carbogen and ARCON and hypoxic cell radiosensitisers can improve the efficacy of radiation and chemotherapy. Hypoxia environment indicates several new methods to treat gastric cancer, and the exogenous markers of tumor hypoxia, HIF-1 inhibitor, and HIF-1 gene therapy will be the focus in the future.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第21期2381-2384,共4页
World Chinese Journal of Digestology
关键词
低氧
胃癌
放疗
化疗
Hypoxia
Gastric cancer
Radiotherapy
Chemotherapy
