摘要
目的:评估放疗与紫杉醇周方案化疗同步治疗鼻咽癌(NPC)的近期疗效。方法:观察2004年1月~2007年6月收治的38例局部晚期的鼻咽癌患者。予以放疗,放疗剂量为70Gy^80Gy/7周~8周,同时行化疗,为紫杉醇加顺铂方案(TP方案):紫杉醇180mg/m2,静脉滴注第1天,顺铂80mg/m2,静脉滴注第1天,21天为一周期。结果:完全缓解率(CR)为94.7%,部分缓解率(PR)为5.3%,总有效率(CR+PR)为100.0%。毒副反应主要为骨髓抑制、消化道反应、放射性口腔炎及放射性皮炎。结论:放疗与紫杉醇周方案化疗同步治疗鼻咽癌患者的近期疗效较为满意,毒副反应患者可以耐受。
Objective： To evaluate the short term response of radiotherapy plus concurrent Paclitaxel chemotherapy for patients with nasopharyngeal carcinoma. Methods： From January 2004 to June 2007, 38 nasopharyngeal carcinoma patients were treated with radiotherapy plus concurrent Paclitaxel chemotherapy. The radiation dose ranged from 70Gy to 80Gy per 7 - 8 weeks. The major regimen of chemotherapy was Paclitaxel 180mg/m^2 IV on day 1, cisplatin 80mg/m^2 IV on day 1,21 days per cycle. Results： The complete response rate was 94.7%, the partial response rate was 5.3%, and the overall response rate was 100.0%. The major toxic effects were myelosuppression, gastrointestinal tract reactions, acute radiation stomatitis and acute radiation dermitis. Conclusion： The short term response of radiotherapy plus concurrent Paclitaxel-cisplatin chemotherapy for nasopharyngeal carcinoma patients is preferable and the toxicity is tolerable.
出处
《肿瘤预防与治疗》
2008年第3期286-288,285,共4页
Journal of Cancer Control And Treatment
关键词
放疗
紫杉醇
鼻咽癌
Radiotherapy
Paclitaxel
Cisplatin
Nasopharyngeal Carcinoma
