摘要
目的探讨胃肠道恶性肿瘤术中腹腔植入缓释氟尿嘧啶的护理方法,寻找预防胃肠道恶性肿瘤局部复发转移的新途径。方法64例行胃肠恶性肿瘤根治术患者,分成术中植入缓释氟尿嘧啶组(治疗组)和对照组,治疗组在瘤床和沿淋巴引流途径分多点植入缓释氟尿嘧啶,观察两组术后伤口愈合情况,有无吻合口漏、肠梗阻、腹膜炎、血象变化及肝肾功能变化,腹腔复发和肝转移等。结果治疗组与对照组术后出现吻合口漏、肠梗阻、腹膜炎以及肠功能恢复均无差异(P>0.05),两组术后白细胞计数、ALT和肌酐较术前有明显增高(P<0.05),但两组间无差异(P>0.05),治疗组腹腔复发和肝转移率较对照组低(P<0.05)。结论胃肠道恶性肿瘤术中腹腔植入缓释氟尿嘧啶进行区域性化疗可提高疗效,且无明显毒副反应,是预防术后复发转移的有效途径,而完善护理配合是治疗成功的重要环节。
Objective To explore the nursing method of intraperitoneal interstitialimplant with sustained-release fluorouracil during operation for advanced gastroenteric carcinoma to prevent the local recurrence of advanced gastroenteric carcinoma after operation. Methods 64 patients with advanced gastroenteric carcinoma were randomly divided into controlled group and sustained-release fluorouracil group. The tumor was surgically removed and sustained-release fluorouracil were implanted multiple point during operation in the tumor cavity to observe the incidence of wound infection, anastomosis leakage, intestinal obstruction and peritonitis. WBC, RBC, ALT and Cr were also observed. Result The difference of side effects and postoperative complications between controlled group and sustained-release fluorouracil group was not obviously.WBC,ALT and Cr were different before and after operation, but the difference of two group was not obviously. The local recurrence and metastasis rate between controlled group and sustained-release fluorouracil group was obviously. Conclusion The way of intraperitoneal interstitialimplant with sustained-release fluorouracil during operation for advanced gastroenteric carcinoma patients can increase effects and reduce toxic side effects, which is very effecticve for preventing postoperative recurrence and metastasis of gastroenteric carcinoma. Moreover the preferable nursing cooperation is of most importance in successful treatment.
出处
《医疗保健器具》
2008年第8期33-35,共3页
Medicine Healthcare Apparatus
基金
广东省医学科研基金立项课题
广东省卫生厅(A2007251)
关键词
胃肠道肿瘤
缓释氟尿嘧啶
化疗
护理
gastroenteric carcinoma
sustained-release fluorouracil
chemotherapy
nursing
