摘要
目的探讨针刺对家兔慢性高眼压及慢性高眼压下前房角组织病理变化的影响及作用机理。方法用后房注射2%α-糜蛋白酶溶液0.1 ml的方法建立家兔实验性慢性青光眼模型。将具有实验性慢性高眼压的36只家兔随机分为针刺组、噻吗心安治疗组和空白对照组,每组12只。各组分别用针刺治疗、滴用0.5%噻吗心安眼液和不予任何治疗,观察每组家兔的眼压变化和前房角组织的病理变化。结果针刺组与空白对照组比较眼压明显下降(P<0.01),与噻吗心安组比较差异无显著性(P>0.1);针刺组的小梁网和Schlemm管结构较对照组清晰,小梁网缩窄减轻。结论针刺具有降低家兔实验性慢性高眼压的作用,针刺能够改善小梁网功能。
OBJECTIVE To investigate effect of acupuncture treatment on experimental chronic ocular hypertension and anterior chamber angle tissue histopathological change in rabbits.METHODS Model of chronic ocular hypertension was induced in rabbits by injection of 0.1？ml of 2% chymotrypsin into posterior chamber.Thirty-six rabbits with chronic experimental ocular hypertension were randomly divided into acupuncture group,timolol group,and normal control group.There were 12 rabbits in each group.The rabbits were treated with acupuncture in the acupuncture group,with eye drops of 0.5% timolol in the timolol group and without any treatment in normal control group.Intra ocular pressure（IOP） and anterior chamber angle tissue histopathological change were observed in each group.RESULTS The average IOP of acupuncture group was lower than that of normal control group（P〈0.01）.There was no significant difference between acupuncture group and timolol group（P〉0.1）.The structures in the trabecular meshwork and Schlemm′s canal were clear.Constriction of the trabecular meshwork was alleviated.CONCLUSIONS When acupuncture was performed in the rabbits with experimental chronic ocular hypertension,their IOP could be reduced,and function of the trabecular meshwork could be reduced.
出处
《中国中医眼科杂志》
2008年第4期213-215,共3页
China Journal of Chinese Ophthalmology
基金
广东省中医药局资助项目(102123)
关键词
针刺
实验性慢性高眼压
兔
acupuncture
experimental chronic ocular hypertension
rabbit
