摘要
目的探讨bcl-2、bcl-6、CD10在弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DL-BCL)中的表达及意义。方法应用免疫组织化学SP法,检测60例弥漫性大B细胞淋巴瘤标本中bcl-2、bcl-6、CD10蛋白的表达水平。结果bcl-2、bcl-6、CD10在60例弥漫性大B细胞淋巴瘤中的表达率分别为55.0%(33/60)、48.3%(29/60)、46.7%(28/60),其中CD10(+)/bcl-6(+)15例,25%;CD10(+)/bcl-6(-)13例,21.7%;CD10(-)/bcl-6(+)14例,23.3%;CD10(-)/bcl-6(-)18例,30%。CD10(+)/bcl-6(+)与CD10(-)/bcl-6(-)中bcl-2的表达差异具有统计学意义。结论bcl-2有望成为DLBCL亚分类的指标。
Objective To investigate the expression of bcl-2, bcl-6, CD10 protein and their significance in subgroups of diffuse large B-cell lymphoma. Methods Immunohistochemistry technique （SP method） was used to assess the expression levels of bcl-2, bcl-6, CD10 protein in 60 cases of diffuse large B-cell lymphoma. Results Expression of bcl-2, bcl-6 and CD10 protein was found in 33/60 （55. 0%）, 29/60 （48.3%） ,28/60（46. 7%） cases, respectively. The CD10/bcl-6 patterns were as follows： CD10（ ＋ ）/bcl- 6（ ＋ ） 15 cases,25%;CD10（ ＋ ）/bcl-6（ - ）13 cases,21.7% CD10（ - ）/bcl-6（ ＋ ）14 cases,23. 3% ;CD10 （ - ）/bcl-6（ - ）18 cases,30% Expression levels of the bcl-2 protein in CD10（ ＋ ）/bcl-6（ ＋ ） pattern was higher than that in CD10（ - ）/bcl-6（ - ）pattern （P = 0. 037）. Conclusion The bcl-2 protein may be of value to distinct subgroups of diffuse large B-cell lymphoma.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2008年第8期563-565,共3页
Cancer Research on Prevention and Treatment
基金
福建省自然科学基金资助项目(Z0516086)
