摘要
目的观察亚低温治疗对重型颅脑损伤患者血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平及患者预后的影响。方法重型颅脑损伤66例随机分为对照组和亚低温组,每组33例,对比观察2组患者伤后1 d、3d、7 d血清IL-6和TNF-α水平,并评价其预后。结果亚低温组患者在1 d、3 d、7 d时血清中IL-6和TNF-α水平明显低于对照组(P<0.05),亚低温组预后良好率明显高于对照组(P<0.05)。结论亚低温可明显降低重度颅脑损伤后血清IL-6和TNF-α水平,并可改善其预后。
Objective To investigate the influence of hypothermia treatment on the level of interleukin-6.（IL-6） and tumor necrosis factor（TNF-α） in patients with severe craniocerebral injury. Methods Sixty-six patients with severe craniocere- bral injury were equally divided into control group and hypothermia group（ n = 33 ）. The levels of serum IL-6 and TNF-α were determined and compared on the first day, the third day and the seventh day after injury. Results The levels of serum IL-6 and TNF-α were significantly lower in hypothermia group than those in control group （ P 〈 0.05 ） 1 day, 3 day and 7 day after injury. The rate of good prognosis in hypothennia group was significantly higher than that in control group （ P 〈 0.05 ）. Conclusion Hypothermia treatment can decrease the levels of serum IL-6 and TNF-α in patients with severe craniocerebrat injury and improve the prognosis of patients.
出处
《新乡医学院学报》
CAS
2008年第5期501-503,共3页
Journal of Xinxiang Medical University
关键词
亚低温
颅脑损伤
肿瘤坏死因子-Α
白细胞介素-6
hypothermia
severe craniocerebral injury
tumor necrosis factor alpha
Interleukin-6
