摘要
目的:建立注射用丹参(冻干)中微量元素含量的测定方法。方法:样品经微波消解后,以铟为内标,用电感耦合等离子体质谱(ICP—MS)测定注射用丹参(冻于)中 As、B、Ba、Be、Mn、Pb、Zn、Cd、Co、Cr、Cu、Fe、Ni、V、Hg 等15种微量金属元素的含量。结果:该方法对各元素的检出限为0.001～3.591 ng·g^(-1),加标回收率为90.4%～110.4%,标准物质茶树叶的测定值与标示值基本吻合。结论:所建立的方法快速、准确、灵敏度高,可以用于测定注射用丹参(冻干)中微量金属元素的含量。
Objective：To establish a method for the determination of microelements in Danshen injection. Methods： A method was studied for the assay of fifteen microelements such as As, B, Ba, Be, Mn, Pb , Zn, Cd, Co, Cr, Cu,Fe,Ni,V and Hg in Danshen injection by microwave digestion- inductively coupled plasma mass spectrometry （ ICP - MS） with In as internal standard. Results：Detection limits for above elements were between 0. 001 - 3.591 ng · g^-1, the recoveries were between 90.4% - 110.4%. The results obtained showed close agreement with the reference values standard reference material of tea leaves. Conclusions：The method is accurate, reliable and applicable for the determination of microelements in Danshen injection.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2008年第8期1297-1301,共5页
Chinese Journal of Pharmaceutical Analysis
