摘要
目的揭示感染性心内膜炎(IE)的流行病学特点,以期提高IE的防治水平。方法收集四川大学华西医院于1996年7月至2006年6月期间治疗的IE病例,按改良的Duke标准纳入研究对象。按时间顺序,将资料分为1996年7月至2001年6月和2001年7月至2006年6月2组,比较IE的流行病学变迁。结果IE的发病年龄显著增大(P<0.01);60岁以上患者增加(P<0.05),30岁以下患者减少(P<0.05)。风湿性心瓣膜病基础上发生IE的构成比明显减少(P<0.05),瓣膜退行性病变基础上发生IE的构成比显著增加(P<0.05)。IE致病菌中,草绿色链球菌和金黄色葡萄球菌所占比例没有明显变化;真菌比例显著增加(P<0.05)。结论IE的流行病学已发生明显变化,平均发病年龄显著增大。IE的基础心脏疾病中,风湿性心脏病减少,先天性心脏病相对增加,且已超过风湿性心脏病,成为IE最常见的基础心脏疾病。IE的致病菌中,草绿色链球菌和金黄色葡萄球菌所占比例没有明显变化,草绿色链球菌仍是IE最常见的致病菌,真菌已有显著增加趋势。
Objective To reveal the epidemiological characteristic of infective endocarditis for improving its prevention and cure rate. Methods All cases who met Duke Criteria from west China Hospital of SiChuan University during the late 10-year period were collected. 381 cases were divided into two groups, their epidemiological features were retrospective studied. Results The average age onset of infective endocarditis had increased obviously （P〈0.01）. In underling heart diseases of infective endocarditis, the rheumatic heart disease had decreased significantly （P〈0.05）, the valve degenerative disease was increasing,P〈0.05. There wasn＇t marked change in the proportion of Viridans Streptococcus and Staphylococcus aureus in pathogen of infective endocarditis, but the proportion of fungi had raised obviously,P〈0.05. Conclusion The onset age of infective endocarditis had increased evidently during the past years, and the risk factors of infective endocarditis had undergone significant diversification. In underling heart diseases of infective endocarditis, the rheumatic heart disease decline obviously, the congenital heart disease increases correspondingly, and has outnumbered the rheumatic heart disease as the most common risk factor of infective endocarditis. In the pathogen of infective endocarditis. Although the number of Staphylococcus anreus rise gradually, the predominant organism is still Viridans Streptococcus; the proportion of epiphyte had increased evidently.
出处
《中国心血管病研究》
CAS
2008年第9期647-649,共3页
Chinese Journal of Cardiovascular Research
