摘要
目的:以常用中药材当归为例,依据其所含活性成分变化规律,预测当归药材的保质期,并提出中药材亟需建立保质期的问题。方法:经典恒温法对当归药材进行加速实验并预测其保质期,利用高效液相色谱法测定其中的主要化学成分含量。结果:阿魏酸松柏酯和Z-藁本内酯的化学动力学方程分别为:lgk=-5 152.1/T+13.811(r=0.9985)和lgk=-4 064.6/T+10.4(r=0.9997),由此推算出室温下的温度常数k25℃,进而计算出各自含量下降10%时间t0.9分别约为13,7 d,与验证实验结果基本一致。结论:该方法为当归药材保质期的建立提供了参考依据,说明了建立中药材保质期的必要性。
Objective： To predict the shelf life of Chinese Angelica by investigating the stability of its active components. Method ： The classic homeothermia method was used for forecast the shelf life, and HPLC was applied for quantitative determination of chemical compounds in Chinese Angelica. Result ： The correlation equations, thermal constant at ambient temperature （ k25 ℃） and shelf life （to. 9 ） for coniferyl ferulate and Z-Ligustilide were lgk = - 5 152. 1/T ＋ 13.8 （r = 0. 998 5 ）, 3.33 × 10^-4, 13 d and lgk = - 4 064. 6/T ＋ 10. 4 （ r = 0. 999 7 ）, 5.91 × 10^-4, 7 d, respectively. Conclusion： The shelf life of Chinese Angelica has been established, which suggests that it is very important for ensuring the safety and efficacy of Chinese crude drug.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2008年第16期1997-2001,共5页
China Journal of Chinese Materia Medica
基金
江苏省方剂研究重点实验室开放课题基金(022021014003)
关键词
中药材
保质期
当归
经典恒温法
化学成分
chinese crude drug
shelf life
Chinese Angelica
classic homeothermia method
chemical components
