摘要
系统性红斑狼疮（SLE）是一种自身免疫系统疾病、可累及全身各个系统、脏器和组织，调节性T细胞（Tr）在其发生发展中发挥了重要的作用。目前所知的Tr具有免疫抑制的作用，包括两个亚群——CD4^＋Tr（CD4^＋CD25^＋Tr、Tr1和Th3细胞）和CD8^＋Tr（Ts细胞和CD8^＋CD25^＋T细胞）。全面了解Tr和人类SLE的关系是在此领域发展新的免疫学治疗方法的基础。
Systemic lupus erythematosus（SLE） is an autoimmune disease. Almost all the systems could be involved. Regulatory T cells play an important role in the occurrence and development of SLE. At present , regulatory T cells are distinguished as two subpopulations according to their immune suppressive function CD4^＋ regulatory T ceils which include CD4^＋ CD25^＋ Tr,Tr1 and Th3, and CD8^＋ regulatory T cells, which include Ts and CD8^＋ CD25^＋ T cells. A full understanding of the relationship between regulatory T cells and human SLE is the basis for developing novel immunological therapy approach in this area.
出处
《国际免疫学杂志》
CAS
2008年第5期371-374,共4页
International Journal of Immunology
