摘要
目的:研究长期的运动对I和II型糖尿病周围神经病变的影响。方法:83名糖尿病参与本研究。随机分为两组:即运动组43名,完成4h/W的轻快的跑台上行走,运动强度以50%-85%的心率。对照组40名病人。测量患者下肢振动知觉阈(VPT),神经传导速度(NCV)和神经动作电位振幅(NAPA)。结果:发现两组腓侧和腓肠肌运动神经元的NCV有显著差异(P<0.001)。结果:对照组与运动组比较,发展为运动神经病和感觉神经病的百分比显著增高(分别为21%和0.0%,P<0.05;32%和4.3%,P<0.05)。对照组与运动组比较,VPT增加明显(32.1%和13.6%,P<0.05)。结论:长期的有氧运动可以预防DPN的发生和发展。
Background： Diabetes is the most important cause of peripheral neuropathy （DPN）. No effective treating methods have been found. Objective： Examine the effect of long - term exercise training on the development of DPN in both types of diabetic patients. Methods： Eight - three diabetic patients without signs and symptoms of peripheral DPN were enrolled, randomized, and subdivided into two groups： 43 diabetic participants who performed a prescribed and supervised 4 h/week walking on a treadmill at 50% to 85% of the heart rate reserve （EXE） ,and a control group of 47 diabetic participants （CON）. Vibration perception threshold （VPT）, nerve conduction velocity （NCV）, and nerve action potential amplitude （NAPA） in the lower limbs were measured. Results： We found significant differences on △ （delta） in NCV for both peroneal and sural motor nerve between the EXE and CON groups during the study period（ P 〈 0.001, for both）. Research findings ： The percentage of diabetic patients that developed motor neuropathy and sensory neuropathy was significantly higher in the CON than in the EXE group （ 21% vs. 0.0% , P 〈 0.05, and 32% vs. 4.3 % , P 〈0.05 ,respectively）. In addition, the percentage of diabetic patients who developed increased VPT （25V） during the study was significantly higher in the CON than in the EXE group （32. 1%vs. 13.6% ,P 〈0.05）. Change on Hallux VPT from baseline to the end of the study was significantly different between the EXE and CON groups （ P 〈 0.05） ; no significant change in Malleolus VPT between the two groups occurred. Conclusions： This study suggests, for the first time, that long - term aerobic exercise training can prevent the onset and development of DPN.
出处
《成都体育学院学报》
CSSCI
北大核心
2008年第9期78-80,共3页
Journal of Chengdu Sport University
关键词
糖尿病周围神经病变
跑台行走
有氧运动
diabetic peripheral neuropathy, treadmill exercise, aerobic exercise
