摘要
目的：探讨原发不孕患者伴有不同病因时，如何选择IVF（体外受精）／ICSI（胞浆内单精子显微注射）方案。方法：将200例200个周期行IVF方案的原发性不孕症患者，根据有无明确导致不孕的因素分为A、B两大组，再按受精率（受精卵子教／取卵所获的MII期卵子总数）高低划分为受精率高、低各两组，比较4组之间人数所占比例、优质胚胎教、妊娠率有无差异；观察受精率低人群不孕年教分布；比较受精率高、低两组平均不孕年教有无差异。结果：受精率低的患者例教在A组所占比例显著高于B组，差异有显著性（受精率高组VS受精率低组：χ^2=18．632，P〈0．05），B组妊娠率和优质胚胎平均教低于A组；总体受精率低的患者平均不孕年教长于受精率高的患者，但差异无显著性（受精率高组VS受精率低组：6．26±3．287VS5．75±2．795；P〉0．05），受精率低的患者不孕年教分布在5～7年。结论：无明确病因且多年不孕的患者，需告知有不受精的风险，选择ICSI或部分ICSI是有必要的，而这部分患者如能有足够的优质胚胎移植，妊娠率则较高。
Objective：To determine an optimal technique IVF or ICSI for primary infertility patients with different etiological factors undergoing assisted reproduction treatment （ART）. Methods： Two hundred cycles of 200 patients undergoing IVF were divided into two groups ： group A （ n = 82 ） without definite cause of infertility ; group B （ n = 118 ） with definite cause of infertility. According to the fertilization rate （ number of fertilized oocytes/sum of retrieved M Ⅱ oocytes）, patients were further devided into low （ fertilization rate ≤50% ） and high（ 〉 50% ） fertilization groups. Using of statistics to analysis ratios of patients, pregnancy rates among 4 groups and distribution of infertility years of low fertilization group. Average infer- tility years were compared between low and high fertilization groups. Results： Ratio of patients with low fertilization rate of group A was higher than that of group B（ χ^2 = 18. 632 ,P 〈0.05）, however, pregnancy rate and average number of high quality embryos of group A were higher than those of group B. Infertility years of low fertilization group were longer than those of high fertilization group（ 6.26± 3. 287 vs 5.75 ± 2.795, P 〉 0.05 ）, and its distribution was mainly from 5 to 7 years. Conclusions： There is risk of infertilization to the patients without definite cause of infertility. ICSI or half-ICSI can help to avoid complete fertilization failure. Futhermore, if they have high quality embryos to transfer, pregnancy rate may be high.
出处
《现代妇产科进展》
CSCD
北大核心
2008年第8期579-581,共3页
Progress in Obstetrics and Gynecology
