摘要
目的观察阿奇霉素、阿莫西林、奥美拉唑三联疗法根除十二指肠球部溃疡患者的幽门螺杆菌(Hp)的临床疗效及治疗费用,并与克拉霉素(Clarithromycin)、阿莫西林、奥美拉唑联合疗法进行比较。方法将经胃镜检查证实为十二指肠球部溃疡并有Hp感染的200例患者,随机分为A、B两组。A组(110例)患者口服阿奇霉素,500mg/d,仅疗程开始的前3d服用;奥美拉唑40mg,1次/d,阿莫西林1000mg,2次/d,共1周。B组(90例)患者口服克拉霉素500mg,2次/d,共1周;奥美拉唑与阿莫西林的剂量与疗程同A组。疗程结束4周后胃镜复查溃疡愈合情况,14C-尿素呼气试验复查Hp根除情况。结果Hp根除率:A组和B组分别为92.7%(102/110)、93.3%(82/90),两组间差别无显著性(P>0.05);溃疡愈合率:A组和B组分别为96%(96/100)、95.1%(78/82),两组间差别无显著性(P>0.05)。结论阿奇霉素、阿莫西林、奥美拉唑三联疗法治疗1周的方案与克拉霉素、阿莫西林、奥美拉唑方案疗效相当。
Objective To observe the efficacy and therapy cost of Azithromycin, Amoxicillin and Omeprazole based triple therapy on eradication of Helicobacter pylori in the patients with duodenal ulcer, and compare with Clarithromycin, Omeprazole and Omeprazole based triple therapy. Method- s Total 200 patients with duodenal ulcer and Hp infection confirmed by gastroscopy, divided into two groups A and B randomly. Group A （ 110 cases） the patients take orally Azithromycin, 500rag/d, the beginning 3 days only in period of treatment; Omeprazole 40mg, once/d, Amoxicillin 1000mg, twice/ d, altogether 1 week. Group B （90 cases） the patients take orally Clarithromycin 500rag, twice/d, al- together 1 week; the dosage and treatment process of Omeprazole and Amoxicillin are same with group A. Review the ulcer healing situation by gastroscopy after 4 weeks of treatment process, 14C urea breath test to review the Hp eradicate situation. Results Hp eradication rate： group A and group B were 92.7% （102/110）, 93.3% （82/90）, there were no significant difference between two groups （P 〉 0.05） ; Ulcer healed rate： group A and group B were 96% （96/100） ,95.1% （78/82）, there were no significant difference between two groups （P 〉 0. 05） . Conclusion The efficacy similar of Azithromycin, Amoxicillin and Omeprazole based triple therapy for one week process and Clarithromy- cin, Amoxicillin and Omeprazole based triple therapy. Azithromycin, Amoxicillin and Omeprazole based triple therapy have those benefits in high rate of eradication, the low cost of therapy, and fewer adverse reactions.
出处
《医药论坛杂志》
2008年第18期18-19,共2页
Journal of Medical Forum
