摘要
在乙醇钠催化下,将3-(1,2亚丙二硫基)亚甲基-2,4-二羰基戊烷与2-羰基苯氧乙酸进行缩合反应,获得了柔性二元酸配体1[4-(1,2-亚丙二硫基)亚甲基-3,5-二羰基-1,6-庚二烯-1,7-二(2-羰基苯)氧乙酸(LH2)].再将配体1与二正丁基氧化锡进行脱水反应,获得新型二正丁基锡羧酸酯配合物2.采用元素分析、1H NMR、IR及晶体结构测定等手段对配体1和配合物2进行了结构表征,配合物2是以菱形环Sn2O2为中心对称的二聚体结构,中心菱形环通过氧原子与2个环外锡原子相连.每个羧基分别与环内锡和环外锡原子配位,形成2个对称的六元环,3个环呈梯形排列,将整个分子分割成2个对称的二十二元大环.初步研究了其杀菌活性和抗癌活性.
4-（1,2-Dithiopropylene） methylene-3,5-dioxo-1,6-heptadiene-1,7-di-o-phenoxyacetic acid （ 1 ） was synthesized through the reaction of 3-（1,2-dithiopropylene） methylene-2,4-dioxo pentane with 2-formylphenoxyacetic acid under the catalysis of sodium ethoxide. The new di-n-hutyltin carboxylate complex 2 was synthesized by the reaction of the complex 1 with di-n-butyltin oxide. Ligand 1 and complex 2 were characterized via elemental analysis, ^1H NMR, IR and X-ray single crystal diffraction. The structure of complex 2 is a centrosymmetric dimer built up around the rhombus cyclic Sn2O2 four-membered ring, and the rhombus ring joins two exo-cyclic Sn atoms by O atoms. Each carboxyl group was coordinated with endo- and exo-cyclic Sn atoms respectively forming two symmetric six-membered ring. The three rings are in trapezoidal arrangement dividing the complex 2 into two big symmetric twenty-two membered ring. The complex shows antibiotic and anti-tumour activities in vitro experiments.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2008年第9期1781-1785,共5页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:200472014)
中国博士后科学基金(批准号:2005038561)
吉林省科学技术厅科研基金(批准号:20060571
20070406)资助
关键词
有机锡(Ⅳ)
双大环二正丁基锡羧酸酯
晶体结构
杀菌活性
抗癌活性
Organotin （Ⅳ）
Dimacrocyclic di-n-butyltin carboxylate
Crystal structure
Antibiotic activity
Anti-tumour activity
