摘要
目的观察静脉用国产两性霉素B对血液病患者侵袭性真菌感染（IFI）的临床疗效及其安全性。方法选择121例血液病患者静脉使用两性霉素B，剂量为5～50mg／d，用药时间5～101d，中位数为19d，并对用药前后患者肝、肾功能及电解质进行监测。结果静脉使用两性霉素B临床总有效率为67．3％，真菌清除率为66．7％。不良反应包括寒战、高热、低钾血症、肝。肾功能损害、胃肠道反应、静脉炎和皮疹。结论只要合理应用，对其不良反应进行积极防治，两性霉素B仍是较为安全有效的一线抗真菌药物。
Objective To observe the efficacy and safety of amphotericin B for treatment of invasive fungal infections（ IFI ） in patients with hematologic diseases. Methods 121 patients were given amphotericin B 5 - 50 mg/d for 5 - 101 d with a median of 19 d. Results The clinical efficacy rate was 67.3% , and fungal elimination rate 66.7%. The adverse events included rigor and fever, hypokalaemia, hepatic damage, nephrotoxicity, nausea and vomiting, phlebitis and tetter. Conclusion Amphotericin B is still a high-efficiency drug in the treatment of IFI, although it has many side effects. With monitoring of hepatic and renal function, it is still a relatively safe and effective drug.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2008年第9期619-622,共4页
Chinese Journal of Hematology
关键词
两性霉素B
侵袭性真菌感染
血液病
Amphotericin B
Invasive fungal infection
Hematologic diseases
