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YKL-40在恶性肿瘤中的研究与应用 被引量：4

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摘要 YKL-40是一种在多种恶性肿瘤细胞中高度表达和分泌的蛋白,在细胞的增殖、分化、肿瘤周围组织血管发生等起重要作用,是肿瘤细胞生存和抗凋亡因子。它在多种恶性肿瘤患者血清中的水平显著高于良性肿瘤患者和健康人,且高水平YKL-40的恶性肿瘤患者病情恶化期和总体生存期短、预后差。因此YKL-40可作为恶性肿瘤诊断、患者病情和预后评价的标志物及未来抗肿瘤治疗的一个新靶点。
作者 程明刚 郝艳华 姚吉龙
机构地区 深圳市宝安区人民医院/南方医科大学附属宝安医院
出处 《国际检验医学杂志》 CAS 2008年第9期803-805,共3页 International Journal of Laboratory Medicine
基金 深圳市科学技术局资助项目(JH200505300500A) 深圳市宝安区科技局资助项目(No.2005108)
关键词 凋亡调节蛋白质类 肿瘤 生物学标记 诊断 预后
分类号 R730.2 [医药卫生—肿瘤]
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参考文献15

  • 1Junker N, Johansen JS, Hansen LT, et al. Regulation of YKL- 40 expression during genotoxic or microenvironmental stress in human glioblastoma cells[J]. Cancer Sci, 2005, 96(3): 183-190.
  • 2Nishikawa KC, Millis AJ. gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells [J]. Exp Cell Res, 2003, 287(1) : 79-87.
  • 3Ling H, Recklies AD. The chitinase 3 like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha [J]. Biochem J, 2004, 380(Pt 3): 651-659.
  • 4Nigro JM, Misra A, Zhang L, et al. Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma [J]. Cancer Res, 2005, 65(5): 1678-1686.
  • 5Mohanty AK, Singh G, Paramasivam M, et al. Crystal structure of a novel regulatory 40 kDa mammary gland protein (MGP-40) secreted during involution [J]. J Biol Chem, 2003, 278 (16): 14451-14460.
  • 6Dupont J, Tanwar MK, Thaler HT, et al. Early detection and prognosis of ovarian cancer using serum YKL 40 [J]. J Clin Oncol,.2004, 22(16) : 3330-3339.
  • 7Diefenbach CS, Shah Z, Iasonos A, et al. Preoperative serum YKL 40 is a marker for detection and prognosis of endometrial cancer [J]. Gynecol Oncol, 2007, 104(2): 435-442.
  • 8Johansen JS, Christensen IJ, Riisbro R, et al. High serum YKL 40 levels in patients with primary breast cancer is related to short recurrence free survival [J]. Breast Cancer Res Treat, 2003, 80 (1): 15-21.
  • 9Jensen BV, Johansen JS, Price PA. High levels of serum HER-2/neu and YKL 40 independently reflect aggressiveness of metastatic breast cancer [J]. Clin Cancer Res, 2003, 9 ( 12) : 4423- 4434.
  • 10Johansen JS, Drivsholm L, Price PA, et al. High serum YKL-40 level in patients with small cell lung cancer is related to early death [J]. Lung Cancer, 2004, 46(3): 333-340.

同被引文献44

  • 1王国金,卫小春,郝一勇.YKL-40在骨关节炎发病中的作用[J].中华风湿病学杂志,2006,10(1):52-55. 被引量：9
  • 2Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002 [J]. CA Cancer J C1in,2005,55(2) :74- 108.
  • 3You WC,Jin F,Devesa S,et al. Rapid increase in colorectal cancer rates in urban Shanghai, 1972-97, in relation to dietary changes[J].J Cancer Epidemiol Prev,2002,7(3) :143-146.
  • 4Johansen JS,Williamson MK, Rice JS, et al. Identification of proteins secreted by human osteoblastic cells in culture[J]. J Bone Miner Res,1992,7(5) :501-512.
  • 5Johansen JS,Jensen BV,Roslind A,et al. Serum YKL 40,a new prognostic biomarker in cancer patients[J].Cancer Epidemiol Biomarkers Prey,2006,15(2) :194-202.
  • 6Jensen BV,Johansen JS, Price PA. High levels of serum HER-2/ neu and YKL-40 independently reflect aggressiveness of metastatic breast eancer[J]. Clin Cancer Res,2003,9(12):4423-4434.
  • 7Dupont J, Tanwar MK, Thaler HT, et al. Early detection and prognosis of ovarian cancer using serum YKL 40[J]. J Clin Onto, 2004,22(16) :3330-3339.
  • 8Hogdall EV,Johansen JS, Kjaer SK,et al. High plasma YKL 40 level in patients with ovarian cancer stage Ⅲ is related to shorter survival[J]. Oncoi Rep,2003,10(5) : 1535-1538.
  • 9Locker GY, Hamilton S, Harris J ,et al. ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer[J]. J Clin Oncol,2006,2,1(33) :5313-5327.
  • 10Johansen JS,Bojesen SE, Mylin AN,el al. Elevated plasma YKL- 40 predicts increased risk of gastrointestinal cancer and decreased survival after any cancer diagnosis in the general population[J].J Clin Oncol. 2009,27(4):572-578.

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国际检验医学杂志
2008年 第9期

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