摘要
为探讨端粒酶活化在胃癌发生发展中的作用，本文采用ＴＲＡＰ法对７２例胃镜胃粘膜活检标本端粒酶活性进行检测，结果发现，胃癌端粒酶阳性率为８５．０％（１７／２０），萎缩性胃炎、肠上皮化生、异型增生及胃腺瘤性息肉端粒酶阳性率分别为２８．６％（１０／３５）、１６．７（１／６）、３３．３％（１／３）及１００％（２／２）。胃癌组织端粒酶阳性率与肿瘤部位、大体类型及组织学分类无明显相关。以上结果提示，胃粘膜活检标本端粒酶活性的检测对阐明胃癌的发生发展过程，胃粘膜癌变的预测及胃癌的早期诊断可能具有重要意义。
Telomerase activity in 72 endoscopic specimens of gastric mucosa was examined to elucidate its genesis of gastric cancer.Telomerase repeat amplitude protocol(TRAP)was adopted for assays.The detected positive rate of telomerase activity varied as follows:85 0%(17/20) in gastric cancer,100 0%(2/2)in gastric polyp,33 3%(1/3)in intestinal dysplasia,16 7%(1/6)in intestinal metaplasia,28 6%(10/35) in chronic atrophic gastritis and 0%(0/6) in chronic superficial gastritis.Telomerase activity in gastric cancers was not relative with tumor location ,macroscopic and microscopic morphology.The results indicated that the expression of telomerase may play a crucial role in the process of gastric tumor genesis.The detection of telomerase may be helpful in predicting malignant change of gastric mucosa and early diagnosis of gastric cancers.
出处
《中华消化内镜杂志》
1997年第5期298-300,共3页
Chinese Journal of Digestive Endoscopy
基金
国家自然科学基金
关键词
癌前病变
端粒酶
胃肿瘤
检测
Gastric Cancer Premalignant Lesion Telomerase
