摘要
研究人类白细胞抗原（HLA）与妊娠高血压综合征（PIH）关联的机制。采用非同位素标记的聚合酶链反应一顺序特异性寡核苷酸探针（PCR／SSO）杂交的方法，对30对PIH患者夫妇及14对正常对照夫妇进行了HLA-DQB1基因型的检测。结果：PIH患者夫妇HLA－DQB1*0502等位基因频率增高。结论：HLA—DQB1*0502可能是PIH的易感基因。
PURPOSE To eXplore the mechanism of association of human leucocyte antigen (HLA) with pregnancy induced hypertension (PIH).METHODS We used polytnerase chain reaction-sequence specific oligonucleotide (PCR/SSO) method(probes labelled by nonradioactive technique) to compare the difference of HLA-DQ β1 allelic frequency distribution between 30 PIH couples and 14 control couples.RESULTS Primary result showed that the allelic freqency of HLA-DQB1 * 0502 was significantly higher in PIH couples than in control couples.CONCLUSIONS OUr result suggests that HLA-DQB1 * 0502 may be the susceptibility gene of PIH.Further study needs to be made.
出处
《上海医科大学学报》
CSCD
1997年第5期373-375,共3页
Journal of Fudan University(Medical Science)
基金
国家自然科学基金!39270689
