摘要
目的研究动员自体骨髓干细胞疗法对合并心力衰竭的急性心肌梗死(AMI)患者心功能的影响。方法30例合并心衰的AMI患者随机分为2组。干细胞动员组15例,于入院后在常规治疗基础上加用粒细胞集落刺激因子(G-CSF)动员自体骨髓干细胞修复心肌梗死部位心肌并促进血管再生;对照组15例按AMI常规治疗。入院后第1天及第4、12周通过心脏超声(UCG)以及核素显像(SPECT)全面评价心功能。结果入院后4周,动员组心肌梗死面积缩小(P<0.05),对照组心肌梗死面积较治疗前无显著改善(P>0.05);与对照组相比,动员组4周时UCG提示左室射血分数及心输出量显著提高,SPECT显示心肌梗死面积缩小(P<0.05);第12周时这些改善进一步加强(P<0.01)。结论骨髓干细胞动员疗法可以提高AMI患者的心功能。
Objective To study the effect of autologous marrow stem cells mobilization on the heart function in patients with acute myocardial infarction（AMI） and heart failure. Methods 30 patients with AMI and heart failure were randomly divided into tow groups, 15 patients in stem cells mobilization group were injected subcutaneously with 5μg/kg granuloeyte-colony stimulating factor（G-CSF） daily for 5 clays in 48 h after onset AMI in addition to standard therapy; and 15 patients in control group were treated with standard therapy alone. In tow groups, heart function was evaluated by UCG and SPECT on lday.4th week and 12th week after admission. Results On 4th week, the infracted size was significantly smaller than that on the first day after AMI in stem cells mobilization group（P〈0.05）, but the infraeted size was not dramatically decreased in control group（P〉0.05）. As compared with control group, an obvious improvement in heart function and in the square of myocardial infarction was found in stem cells mobilization group on the 4th week after AMI （P〈0. 05）, and on the 12th week, these effects were more significant （P〈0.01）. Conclusion Mobilization of autologous marrow stem cells can improve the heart function after my ocardial infarction.
出处
《华中医学杂志》
2008年第5期335-337,共3页
Central China Medical Journal
关键词
骨髓干细胞
动员
急性心肌梗死
心功能
粒细胞集落刺激因子
Bone marrow stem cells
Mobilization
Acute myocardial infarction
Heart function
Granulocyte-colony stimulating factor
