摘要
鸭静脉接种或经眼-鼻-口腔-泄殖腔接种禽流感病毒A/duck/Guangdong/220/2004(H5N1)后,全身多数脏器充血、淤血、出血,血栓形成、组织水肿,以及心、肝、脾、肺、肾、胰、脑、胸腺、法氏囊等许多器官的实质细胞发生坏死或凋亡;主要表现为血管炎、坏死性胰腺炎、萎缩性坏死性胸腺炎和法氏囊炎、脾炎、气管炎、出血性支气管间质性肺炎、病毒性心肌炎、非化脓性脑炎、局灶性病毒性肝炎、溃疡性肠炎、肾小管间质性肾炎和系膜细胞增生性肾小球肾炎等。结果显示,该病毒的致病机制与细胞坏死和细胞凋亡有关,而鸭多脏器严重的病理损伤是其死亡的原因。
Ducks were experimentally inoculated with a highly pathogenic avian influenza virus, A/duck/Guangdong/220/2004 （H5N1） by intravenous and eyes-nares-mouth-cloaca routes, then the micro- and ultra-pathology were investigated. The pathologic lesions characterized by systemic hyperemia, congestions, hemorrhages, thrombosis, edema were observed in multiple organs. And the necrosis and apoptosis occurred in the heart, liver, spleen, lung, kidney, pancreas, encephalon, thymus and bursa of Fabricius etc. The most prominent lesions were vasculitis, necrot- ic pancreatitis, atrophic and necrotic thymusitis and bursatitis, splenitis, tracheitis, hemorrhagic bronchointerstitial pneumonia, viral myocarditis, nonsuppurative encephalitis, local viral hepatitis, ulcerous enteritis, tubulointerstitial nephritis and mesangial proliferatial nephritis. It was suggested that the pathogenic mechanism of the virus is involved in necrosis and apoptosis, and the severe pathologic lesions in multiple organs result in duck death.
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2008年第10期1373-1381,共9页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
广东省科技攻关项目(2004A2090102)
广东省教育厅科学基金项目(Z02003)
