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解脲支原体感染与抗精子抗体阳性及其男性不育症的关系 被引量：5

Relationship Between Ureaplasma Urealyticum Infection and Antisperm Antibody in Infertile Male
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摘要 目的探讨在男性不育症中解脲支原体感染与抗精子抗体阳性的关系。方法采用混合抗球蛋白反应方法,检测50例尿道分泌物解脲支原体Uu阳性不育症患者精液中抗精子抗体,与56例尿道分泌物解脲支原体Uu阴性不育症患者精液中抗精子抗体。结果在106例不育症患者中,解脲支原体Uu阳性组患者精液中抗精子抗体阳性率为68%,明显高于解脲支原体Uu阴性组患者精液中抗精子抗体阳性率16.1%(P<0.01)。结论男性生殖道解脲支原体Uu感染与精液中抗精子抗体的产生有相关性,对男性生育有不良影响。 Objective To investigate the relationship between ureaplasma urealyticurn infection and antisperm antibody in infertile male Methods Ureaplasrna urealyticum infection and antisperm antibody were measured and analyzed in infertile male by using the method of mixed anti-globin reaction. Results Antisperrn antibody positive rate was 68% in total of 106 cases in group of ureaplasma urealyticurn infection, it washigher than in group of non-ureaplasrna urealyticum irfferction, which antisperm antibody positive rate was only 16. 1% （P〈0. 01）. Condusion Ureaplasrna urealyticum infection, could affect production of anfisperm antibody and infertility male
作者 胡建新 何坚 罗战利 孙兆林
机构地区 贵州省人民医院生殖医学中心男科 贵阳医学院附属医院
出处 《贵州医药》 CAS 2008年第10期873-874,共2页 Guizhou Medical Journal
关键词 不育 男性 解脲支原体 抗精子抗体 精液 Infertility Male Ureaplasma urealyticum Antisperm Semen
分类号 R698.2 [医药卫生—泌尿科学] R339.2 [医药卫生—人体生理学]
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参考文献6

  • 1Madar J, Urhanek V, Chaloupkova A, et al. Role of sperm antibodies and cellular autoinmmnunity to sperm in the pathogenesis of male infertility[J]. Ceska Gynekol,2002,67(1) .3.
  • 2Dimitrova DK, Kalaidzhiev SK, Nakov LS, et al. the role of antisperm antibodies in the induction immunologically mediated human infertility [J]. A Kush Ginekol sofiia, 2001,40(3) : 34.
  • 3欧建平,庄广伦.抗精子抗体对辅助生育的影响[J].中华男科学杂志,2003,9(3):214-217. 被引量：34
  • 4Diomitrova D,Kehayov I, Kyurkchiev S, et al. Parification and characterization of sperm coation antige indentified by monlclonal antibody [J]. Andrology, 1993, 25(5) :271.
  • 5Dimitrova DK, Kalaidzhiev SK, Nakov LS, et al. Methods for the seterction of antisperm antibodies associated with immunologically mediated human infertility [J]. A Kush Ginekol sofiia, 2002, 41 (3) ,43.
  • 6Adulrazzak AA, Baker SS, Kyurkchiev S, et al. Role of mycoplasma in male infertility [J]. East Mediterr Health J, 2000,6(1) : 149.

二级参考文献19

  • 1Mazumdar S, Levine AS. Antisperm antibodies : etiology, pathogenesis, diagnosis, and treatment[J]. Fertil Steril, 1998, 70(5) : 799 -810.
  • 2Krapez JA, Hayden CJ, Rutherford AJ, et al. Survey of the diagnosis and management of antisperm antibodies [ J ]. Hum Reprod,1998, 13 (12):3363-3367.
  • 3Vazquez-Levin MH, Kupchick GS, Torres Y, et al. Cystic fibrosis and congenital agenesis of the vas deferens, antisperm antibodies and CF-genotype [ J ]. J Reprod Immunol, 1994, 27 (3) :199-212.
  • 4Gilbert BR, Witkin SS, Goldstein M, et al. Correlation of spermbound immunoglobulins with impaired semen analysis in infertile men with varicoceles. Fertil Steril, 1989, 52 (2) : 469-473.
  • 5Kortebani G, Gonzales GF, Barrera C, et al. Leukocyte populations in semen and male accessory gland function: relationship with antisperm antibodies and seminal quality [ J]. Andrologia,1992, 24 (4) : 197-204.
  • 6Witkin SS, Kligman I, Bongiovanni AM. Relationship between a symptomatic male genital tract exposure to Chlamydia trachomatis and autoimmune response to spermatozoa [ J ]. Hum Reprod,1995, 10 (11) : 2952-2955.
  • 7Greskovich F, Mathur S, Nyberg LM Jr, et al. Effect of early antibiotic treatment on the formation of sperm antibodies in experimentally induced epididymytis [ J ]. Arch Androl, 1993, 30(30) :183-191.
  • 8Liu J, Zhang Y, Shen G, et al. An approach to pathogenesis of male infertilities with anti-sperm antibodies [ J ]. Int J Fertil Menopausal Stud, 1993, 38 (3) : 187-191.
  • 9Cunningham DS, Fulgham DL, Rayl DL, et al. Antisperm antibodies to sperm surface antigens in woman with genital tract infection[J]. Am J Obstet Gynecol, 1991, 164 (3) :791-796.
  • 10Nikolaeva MA, Kulakov VI, Korotkova IV, et al. Antisperm antibodies detection by flow cytometry is affected by aggregation of antigen-antibody complexes on the surface of spermatozoa[J]. Hum Reprod, 2000, 15 (12) : 2545-2553.

共引文献33

同被引文献45

引证文献5

二级引证文献13

贵州医药
2008年 第10期

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