摘要
目的探讨FOLFOX4方案治疗晚期大肠癌近期疗效和不良反应。方法39例晚期大肠癌患者采用奥沙利铂(L-OHP)85 mg/m2,静脉滴入2小时,第1天;亚叶酸钙(CF)200 mg/m2,静脉滴入2小时,5-氟尿嘧啶(5-Fu)400mg/m2静脉推注后予以600 mg/m2持续静脉滴入22小时,第1、2天;每2周重复,28天为1周期。应用3周期后评定疗效。结果39例患者完全缓解(CR)1例,部分缓解(PR)16例,稳定(SD)19例,总有效率43.6%,疾病控制率92.3%,中位至疾病进展时间(TTP)为8个月。骨髓抑制、消化道反应和周围神经毒性为主要不良反应,无IV度不良反应。结论FOLFOX4方案治疗晚期大肠癌有较好疗效,不良反应可耐受。
Objective To observe the short-term efficacy and toxicity of FOLFOX4 in treating patients with advanced eolorectal carcinoma. Methods Oxaliplatin 85 mg/m^2 iv infusion for 2 hours,dl ;CF 200 mg/m^2 iv infusion for 2 hours followed by 5-Fu 400 mg/m^2 iv bolus and 600 mg/m^2 iv infusion for 22 hours,dl ,2. Every two weeks was a cycle. Patients were evaluated after 3 cycles. Results 39 patients entered this study：CR in lcase,PR in 16 cases,SD in 19 cases. The total response rate was 43.6% , the disease control rate was 92. 3% , and the median time to progress was 8 months. The main adverse effects were bone marrow suppression, gastrointestinal toxicity and neurotoxieity. There was no toxicity and adverse effect of grade IV in these patients. Conclusion FOLFOX4 is effective for advanced colorectal carcinoma, and the toxicity is tolerable.
出处
《实用医院临床杂志》
2008年第6期65-67,共3页
Practical Journal of Clinical Medicine
