摘要
目的：探讨奥美拉唑对应激性上消化道溃疡出血的预防效果及机制。方法：将确诊急性颅脑疾病的病人98例,分为两组：在常规治疗基础上奥美拉唑组48例,给予奥美拉唑40 mg,静滴,q 12 h,7天后改为口服或经胃管注入,疗程10～14 d;对照组50例,给予法莫替丁20 mg,静滴,q 12 h,7天后改为口服或经胃管注入,疗程10～14 d。对两组病人上消化道出血的发生率进行对比。结果：对照组上消化道出血的发生率为24.0%,明显高于奥美拉唑组（6.3%）,差异有非常显著意义（P〈0.05）。结论：奥美拉唑能有效地预防应激性上消化道出血,明显降低死亡率。
Objective： To study the effects of omeprazole vs famotidine treating stress ulcer. Methods： 98 patients with severe brain diseases were randomly divided into two groups, omeprazole group （n = 48） and famotidine group （n = 50）, the incidence of upper digestive tract hemorrhage and mortality caused by stress uler were analysed. Results： The incidence of upper digestive tract hemorrhage and mortality was 6.3% in omeprazole group, and 24.0% in famotidine group, respectively. The statistical difference was significant between two groups （ P 〈 0.05 ）. Conclusion： Omeprazole can decrease the incidence of stress ulcer complicating with severe brain diseases and decrease the mortality caused by upper digestive tract hemorrhage.
出处
《药学与临床研究》
2008年第5期380-382,共3页
Pharmaceutical and Clinical Research
