摘要
目的探讨异基因骨髓移植后肾病综合征的临床和病理特点。方法对1例异基因骨髓移植后发生肾病综合征患者的临床、病理资料及治疗进行综合分析。结果本例患者在骨髓移植后28个月发生肾病综合征,在此之前患者有皮肤、口腔和肝脏损害表现;肾脏病理表现为膜性肾病。糖皮质激素及霉酚酸酯治疗后肾病综合征完全缓解。结论异基因骨髓移植后肾病综合征是慢性移植物抗宿主病的肾脏表现,可能为自身免疫性疾病,是移植物对宿主产生的一种排斥反应。肾穿刺活检对该病的诊断和预后判断具有重要价值,免疫抑制剂治疗有效。
Objective To investigate the elinicopathological characteristics of nephrotic syndrome after allogeneic bone marrow transplantation. Methods Clinical and pathological data from a patient with nephrotic syndrome after allogeneic bone marrow transplantation were analyzed. Results The patient developed nephrotic syndrome at month 28 after allogeneic bone marrow transplantation. Other manifestations including skin, mouth and liver damages were observed before nephrotic syndrome. Glomerular histology revealed membranous glomerulonephritis. The patients showed complete remission after treatment with glucocorticosteroids and mycophenolate mofetil therapy. Conclusion Nephrotic syndrome following allogeneic bone marrow transplantation is a rare manifestation of chronic graft-versus-host disease, which might be an autoimmune disease. Renal biopsy plays an important role in the diagnosis and prognosis. Glucocorticosteroids and immune suppressors are effective.
出处
《山西医科大学学报》
CAS
2008年第10期932-934,共3页
Journal of Shanxi Medical University
关键词
骨髓移植
慢性移植物抗宿主病
肾病综合征
bone marrow transplantation
chronic graft versus host disease
nephrotic syndrome
