摘要
目的：为加深对药物性肝炎的病因、临床特点的认识，以提高对药物性肝炎的诊治水平。方法：对1996-2006年初以第1诊断的124例药物性肝炎的临床资料进行回顾性分析。通过原发病、服药史、发病时间、临床表现、实验室检查及停药后的效应，探讨其发病规律及临床特点。结果：引起药物性肝炎的原发病有肺结核、高血压高血脂、风湿性关节炎、类风湿性关节炎、甲亢等。引起药物性肝炎的药物种类较多。临床表现有恶心、食欲不振、乏力、发热、皮肤瘙痒等。结论：引起药物性肝炎的药物种类繁多，中药并非安全无不良反应，要充分了解所使用药物的成分、性能、适应证、禁忌症。由于药物性肝炎临床表现无特异性，易误诊及漏诊，临床医师应提高对本病的认识，做好鉴别诊断。
Objective： To determine the causes and clinical features of drug -induced hepatitis, to enhance the levels of diagnosis and treatment. Methods： Clinical datas of 124 patients with drug - induced hepatitis diagnosed from 1996 to early 2006 were reviewed. Underling diseases, medication history, time of onset, clinical manifestations, laboratory examination, response of cessation of drug medication, and so on were studied with a view to find the causes and chnical features. Results： The diseases related to the drug - induced hepatitis of medi- cation were tuberculosis, hypertension, hyperlipidemia, rheumatic arthritis, rheumatoid arthritis, hyperthyroidism, and so on. There were many drugs could cause drug - induced hepatitis. Chnical manifestations including nausea, anorexia, lassitude, fatigue, fever, pruritus and so on. Conclusion： Many drugs may cause drug- induced hepatitis ; traditional Chinese medicine is not safe without side effects. The ingredient, mechanisms of function and usage, indications and contraindications of drugs should be understood enough before prescription. Clinicians should raise the awareness and understanding of the drug - induced hepatitis so that to avoid misdiagnosis and missed diagnosis due to the non- specific clinical manifestations.
出处
《海南医学院学报》
CAS
2008年第6期710-711,713,共3页
Journal of Hainan Medical University
关键词
肝炎
药物毒性
诊断
Hepatitis
Drug toxicity
Diagnosis
