摘要
【目的】比较单纯胬肉切除术基础上分别联合自体角膜缘干细胞移植术和应用丝裂霉素C治疗原发性翼状胬肉的临床疗效。【方法】将102例患者122眼分为两组,在单纯胬肉切除术基础上分别采用角膜缘干细胞移植术(50例60眼,简称干细胞移植组)和应用丝裂霉素C(52例62眼,简称丝裂霉素组),术后随访1～2年。【结果】角膜上皮平均愈合时间:干细胞移植组为(4.0±0.8)d,丝裂霉素组为(7.3±1.7)d,两组差异有统计学意义(t=14.08,P<0.01)。干细胞移植组2眼复发,复发率为3.3%,丝裂霉素组14眼复发,复发率为22.58%,两组差异有统计学意义(χ2=9.91,P<0.01)。【结论】单纯胬肉切除术联合自体角膜缘干细胞移植术治疗原发性翼状胬肉角膜创面修复快,复发率低,是一种理想的手术方法,值得推广应用。
[Objective] To compare the clinical effects of corneal limbal stem cell transplantation and mitomycin C on the basis of the simple pterygium excision for the treatment of primary pterygium. [Methods]A total of 102 cases （122eyes） were divided into two groups randomly. 50 cases （60eyes） and 52 cases （62eyes） were treated by corneal limbal stem cell transplantation （stem cell group） and mitomycin C （ mitomycin C group） respectively on the basis of the simple pterygium excision. All cases were followed up for 1-2 years after operation. [Results]The average epithelium recovery time of corneal wound were 4.0±0.8 days （stem cell group） and 7.3±1.7 days（mitomycin C group） respectively. The differences of two groups were significant （ t=14.08, P〈0.01）. Two eyes relapsed in the stem transplant group （recurrence rate was 3.3%）, and 14 eyes relapsed in the mitomycin C group （recurrence rate was 22.58%）, and the difference was significant（X^2 = 9.91, P〈0.01）. [Conclusion] The corneal limbal stem cell transplantation has short recovery time and low recurrence rate. It is a valuable surgical method for primary pterygium and should be popularized.
出处
《医学临床研究》
CAS
2008年第10期1791-1792,共2页
Journal of Clinical Research
