摘要
目的观察曲唑酮合并氟西汀治疗抑郁症的疗效及安全性。方法将60例符合入组标准的男性抑郁症患者随机分为研究组(30例)和对照组(30例),研究组予以氟西汀合并曲唑酮治疗,对照组单用氟西汀治疗,疗程8周。于入组时及治疗后1、2、4、8周采用HAMD17项评分、HAMA评分、阿森氏失眠量表(AIS)、亚利桑那性生活问卷(Arizona Sexual Experience Scale,ASEX)、国际勃起功能指数问卷(IIEF-5)进行疗效评定,并进行不良反应评估。结果治疗第八周末两组HAMD总分、体重因子分、认知障碍因子分、迟缓因子分、睡眠障碍因子分的差异具有统计学意义(P<0.05或P<0.01),研究组均低于对照组。研究组AIS(P<0.05)、ASEX(P<0.01)、IIEF-5(P<0.01)评分优于对照组。治疗第八周末研究组临床痊愈26例(86.7%),对照组20例(66.7%),两组比较差异无统计学意义(χ2=3.354,P>0.05)。性功能改善情况:研究组痊愈8例(26.67%),显效16例(53.33%),有效4例(13.33%),无效2例(6.67%);对照组分别为2例(6.67%),13例(43.33%),6例(20%),9例(30%)。两组疗效差异具有统计学意义(χ2=8.765,P<0.05)。两组不良反应无显著差异,均为轻度。结论曲唑酮合并氟西汀对男性抑郁症患者抑郁、睡眠及性功能障碍有较好的疗效,安全性高。
Objective： To explore the efficacy and safety of trazodone plus fluoxetine in treatment of depression patients. Methods ： Sixty depression patients were randomly divided into research group （ n = 30 ） and control group（ n = 30 ）. The patients of research group were treated with trazodone plus fluoxetine while control group with fluoxetine. The study lasted for 8 weeks. Before treatment and at the end of 1st, 2nd, 4th, 8th week after treatment, patients were evaluated with Hamilton rating scale for depression （ HAMD）, Hamilton anxiety scale （HAMA） , Athens insomnia scale （AIS） , Arizona sexual experience scale （ASEX） , the 5 - item version of the international index of erectile dysfunction （ IIEF - 5 ）. Results ： At the end of 8th week after treatment, the total score of HAMD, AIS, ASEX, IIEF - 5 of research group was significantly better than control group（ P 〈0.05 or P 〈0. 01 ）. At the end of 8th week after treatment, the remission rate of research group was 86.7%. The remission rate of control group was 66.7%. There was no significant difference between two groups（X^2= 3. 354, P 〉 0. 05 ）. The remission rate, significant improvement rate, improvement rate and non -response rate of the research group was respectively 26.67%, 53.33% , 13.33% , 6.67%. The control groupwas6.6 7 % , 4 3.3 3 % , 2 0.0 0 % , 3 0.0 0 % . There was significant difference between two groups （X^2 = 8. 765, P 〈 0.05 ）. There was no significant difference between two groups of side effects. Conclusion： Trazodone plus fluoxetine have good efficacy and safety in treating sexual dysfunction, sleep disorder and depressive syndrome in male depression patients.
出处
《上海精神医学》
2008年第5期288-291,共4页
Shanghai Archives of Psychiatry
关键词
曲唑酮
氟西汀
抑郁症
睡眠障碍
性功能障碍
Trazodone Fluoxetine Depression Sleep disorder Sexual dysfunction
